Mechanism by which peripheral galanin increases acute inflammatory pain

Juan Miguel Jimenez-Andrade, Shengtai Zhou, Ammar Yamani, Sandra Valencia De Ita, Gilberto Castañeda-Hernandez, Susan M. Carlton

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Galanin (GAL) is a neuropeptide involved in pain transmission. Intraplantar GAL at low doses enhances capsaicin (CAP)-induced pain behaviors in rat, suggesting an excitatory role for GAL under acute inflammatory conditions. The mechanisms underlying this pronociceptive action have not yet been elucidated. Thus, the present study investigated the role of protein kinase C (PKC) in the GAL enhancement of CAP-induced inflammatory pain. Ipsilateral, but not contralateral, calphostin C, a PKC inhibitor, blocked GAL-induced potentiation of CAP-evoked inflammatory pain in a dose-dependent fashion. Peripheral activation of PKC using the phorbol ester phorbol-12-myristate-13-acetate (PMA) mimicked the pro-nociceptive effect of GAL. These results suggest that GAL enhances acute inflammatory pain through activation of PKC intracellular pathways.

Original languageEnglish (US)
Pages (from-to)113-117
Number of pages5
JournalBrain Research
Volume1056
Issue number2
DOIs
StatePublished - Sep 21 2005

Fingerprint

Galanin
Acute Pain
Protein Kinase C
Capsaicin
Pain
Protein C Inhibitor
Phorbol Esters
Protein Kinase Inhibitors
Neuropeptides
Acetates

Keywords

  • Capsaicin
  • Peripheral sensitization
  • PKC

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Jimenez-Andrade, J. M., Zhou, S., Yamani, A., Valencia De Ita, S., Castañeda-Hernandez, G., & Carlton, S. M. (2005). Mechanism by which peripheral galanin increases acute inflammatory pain. Brain Research, 1056(2), 113-117. https://doi.org/10.1016/j.brainres.2005.07.007

Mechanism by which peripheral galanin increases acute inflammatory pain. / Jimenez-Andrade, Juan Miguel; Zhou, Shengtai; Yamani, Ammar; Valencia De Ita, Sandra; Castañeda-Hernandez, Gilberto; Carlton, Susan M.

In: Brain Research, Vol. 1056, No. 2, 21.09.2005, p. 113-117.

Research output: Contribution to journalArticle

Jimenez-Andrade, JM, Zhou, S, Yamani, A, Valencia De Ita, S, Castañeda-Hernandez, G & Carlton, SM 2005, 'Mechanism by which peripheral galanin increases acute inflammatory pain', Brain Research, vol. 1056, no. 2, pp. 113-117. https://doi.org/10.1016/j.brainres.2005.07.007
Jimenez-Andrade JM, Zhou S, Yamani A, Valencia De Ita S, Castañeda-Hernandez G, Carlton SM. Mechanism by which peripheral galanin increases acute inflammatory pain. Brain Research. 2005 Sep 21;1056(2):113-117. https://doi.org/10.1016/j.brainres.2005.07.007
Jimenez-Andrade, Juan Miguel ; Zhou, Shengtai ; Yamani, Ammar ; Valencia De Ita, Sandra ; Castañeda-Hernandez, Gilberto ; Carlton, Susan M. / Mechanism by which peripheral galanin increases acute inflammatory pain. In: Brain Research. 2005 ; Vol. 1056, No. 2. pp. 113-117.
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