Mechanism of hemoglobin-induced spasm in the isolated middle cerebral artery of the cat.

E. Dora, E. Feher, M. Farago, I. Horvath, Csaba Szabo

Research output: Contribution to journalArticle

5 Scopus citations


a./Great regional differences were observed in the vasospastic effect of hemoglobin. Namely, hemoglobin was far more potent in the middle cerebral artery than in the mesenteric artery. b./The role of potassium ions as well as activation of calcium mobilizing adrenergic, serotoninergic and PGF2 alpha smooth muscle receptors were excluded in the mechanism of cerebral vasospasm induced by hemoglobin. c./First in the literature we showed that atropine significantly attenuates the vasospastic effect of hemoglobin, and hemoglobin releases peptidergic neurotransmitters and modulators from nerve terminals that are located in the adventitia of the middle cerebral artery.

Original languageEnglish (US)
Pages (from-to)533-542
Number of pages10
JournalAdvances in Experimental Medicine and Biology
StatePublished - 1989
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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