TY - JOUR
T1 - Mechanism of hemoglobin-induced spasm in the isolated middle cerebral artery of the cat.
AU - Dora, E.
AU - Feher, E.
AU - Farago, M.
AU - Horvath, I.
AU - Szabo, C.
PY - 1989
Y1 - 1989
N2 - a./Great regional differences were observed in the vasospastic effect of hemoglobin. Namely, hemoglobin was far more potent in the middle cerebral artery than in the mesenteric artery. b./The role of potassium ions as well as activation of calcium mobilizing adrenergic, serotoninergic and PGF2 alpha smooth muscle receptors were excluded in the mechanism of cerebral vasospasm induced by hemoglobin. c./First in the literature we showed that atropine significantly attenuates the vasospastic effect of hemoglobin, and hemoglobin releases peptidergic neurotransmitters and modulators from nerve terminals that are located in the adventitia of the middle cerebral artery.
AB - a./Great regional differences were observed in the vasospastic effect of hemoglobin. Namely, hemoglobin was far more potent in the middle cerebral artery than in the mesenteric artery. b./The role of potassium ions as well as activation of calcium mobilizing adrenergic, serotoninergic and PGF2 alpha smooth muscle receptors were excluded in the mechanism of cerebral vasospasm induced by hemoglobin. c./First in the literature we showed that atropine significantly attenuates the vasospastic effect of hemoglobin, and hemoglobin releases peptidergic neurotransmitters and modulators from nerve terminals that are located in the adventitia of the middle cerebral artery.
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U2 - 10.1007/978-1-4684-5643-1_59
DO - 10.1007/978-1-4684-5643-1_59
M3 - Article
C2 - 2782172
AN - SCOPUS:0024376848
SN - 0065-2598
VL - 248
SP - 533
EP - 542
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
ER -