Mechanism of hemoglobin-induced spasm in the isolated middle cerebral artery of the cat.

E. Dora, E. Feher, M. Farago, I. Horvath, Csaba Szabo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

a./Great regional differences were observed in the vasospastic effect of hemoglobin. Namely, hemoglobin was far more potent in the middle cerebral artery than in the mesenteric artery. b./The role of potassium ions as well as activation of calcium mobilizing adrenergic, serotoninergic and PGF2 alpha smooth muscle receptors were excluded in the mechanism of cerebral vasospasm induced by hemoglobin. c./First in the literature we showed that atropine significantly attenuates the vasospastic effect of hemoglobin, and hemoglobin releases peptidergic neurotransmitters and modulators from nerve terminals that are located in the adventitia of the middle cerebral artery.

Original languageEnglish (US)
Pages (from-to)533-542
Number of pages10
JournalAdvances in Experimental Medicine and Biology
Volume248
StatePublished - 1989
Externally publishedYes

Fingerprint

Middle Cerebral Artery
Spasm
Hemoglobins
Cats
Intracranial Vasospasm
Adventitia
Mesenteric Arteries
Dinoprost
Atropine
Adrenergic Agents
Modulators
Smooth Muscle
Neurotransmitter Agents
Muscle
Potassium
Chemical activation
Ions
Calcium

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Mechanism of hemoglobin-induced spasm in the isolated middle cerebral artery of the cat. / Dora, E.; Feher, E.; Farago, M.; Horvath, I.; Szabo, Csaba.

In: Advances in Experimental Medicine and Biology, Vol. 248, 1989, p. 533-542.

Research output: Contribution to journalArticle

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AU - Szabo, Csaba

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