Mechanism of laser-induced drug delivery in tumors

Rinat Esenaliev, Irina V. Larina, Kirill V. Larin, Massoud Motamedi, B. Mark Evers

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Citations (Scopus)

Abstract

Penetration of anti-cancer drugs (especially macromolecular agents) from blood in tumor cells is limited due to the presence of physiological barriers: tumor capillary wall, slow diffusion in the interstitium, and cancer cell membrane. Interaction of exogenous nano- or microparticles with laser or ultrasonic radiation may enhance drug delivery in tumor cells due to laser- or ultrasound-induced cavitation. Our previous studies demonstrated enhanced delivery of model macromolecular anti-cancer drugs in tissues in vitro when laser or ultrasonic radiation is applied. In this paper, we studied laser-induced cavitation in suspension of strongly absorbing particles and laser-enhanced drug delivery in human colon tumors of nude mice in vivo. Cavitation kinetics and thresholds were measured for carbon and colored polystyrene particle suspensions. Histological examination of control and irradiated tumors with fluorescent microscopy demonstrated that Q-switched Nd:YAG laser irradiation enhances delivery of a model macromolecular drug (FITC-dextran) in tumor blood vessel and interstitium. Enhanced delivery of an anti-cancer drug (5-FU) that is currently used in clinics resulted in tumor necrosis and inhibited tumor growth. Results of our studies suggest that the drug delivery enhancement is due to cavitation produced by local heating of particles with pulsed laser radiation.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages188-196
Number of pages9
Volume3914
StatePublished - 2000
EventLaser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical - San Jose, CA, USA
Duration: Jan 22 2000Jan 27 2000

Other

OtherLaser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical
CitySan Jose, CA, USA
Period1/22/001/27/00

Fingerprint

Drug delivery
Tumors
delivery
drugs
tumors
Lasers
cavitation flow
Cavitation
lasers
cancer
Ultrasonics
laser beams
ultrasonic radiation
Cells
Radiation
dextrans
Dextran
necrosis
blood vessels
Blood vessels

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Esenaliev, R., Larina, I. V., Larin, K. V., Motamedi, M., & Evers, B. M. (2000). Mechanism of laser-induced drug delivery in tumors. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3914, pp. 188-196). Society of Photo-Optical Instrumentation Engineers.

Mechanism of laser-induced drug delivery in tumors. / Esenaliev, Rinat; Larina, Irina V.; Larin, Kirill V.; Motamedi, Massoud; Evers, B. Mark.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3914 Society of Photo-Optical Instrumentation Engineers, 2000. p. 188-196.

Research output: Chapter in Book/Report/Conference proceedingChapter

Esenaliev, R, Larina, IV, Larin, KV, Motamedi, M & Evers, BM 2000, Mechanism of laser-induced drug delivery in tumors. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3914, Society of Photo-Optical Instrumentation Engineers, pp. 188-196, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical, San Jose, CA, USA, 1/22/00.
Esenaliev R, Larina IV, Larin KV, Motamedi M, Evers BM. Mechanism of laser-induced drug delivery in tumors. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3914. Society of Photo-Optical Instrumentation Engineers. 2000. p. 188-196
Esenaliev, Rinat ; Larina, Irina V. ; Larin, Kirill V. ; Motamedi, Massoud ; Evers, B. Mark. / Mechanism of laser-induced drug delivery in tumors. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3914 Society of Photo-Optical Instrumentation Engineers, 2000. pp. 188-196
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