Mechanism of lithium-induced augmentation of T-cell proliferation

Eugene J. Kucharz, Stanislaw Sierakowski, Nigel D. Staite, James Goodwin

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The mechanism whereby lithium augments mitogen-stimulated T-cell proliferation was investigated. Lithium in a concentration of 5mM caused a significant increase in interleukin 2 (IL-2) production after phytohemagglutinin (PHA) stimulation. Lithium also caused an increase in interleukin 1 production from peripheral blood monocytes. Lithium did not influence the expression of IL-2 receptors on T-cells. However, lithium did result in increased proliferative response to IL-2 in an IL-2 responsive cell line. Thus, lithium influences the T-cell proliferation response to mitogens in several ways, by stimulation of lymphokine and monokine production as well as by augmenting the response of IL-2 responsive cells to IL-2.

Original languageEnglish (US)
Pages (from-to)253-259
Number of pages7
JournalInternational Journal of Immunopharmacology
Volume10
Issue number3
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Lithium
Interleukin-2
Cell Proliferation
T-Lymphocytes
Mitogens
Monokines
Lymphokines
Interleukin-2 Receptors
Phytohemagglutinins
Interleukin-1
Monocytes
Cell Line

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Mechanism of lithium-induced augmentation of T-cell proliferation. / Kucharz, Eugene J.; Sierakowski, Stanislaw; Staite, Nigel D.; Goodwin, James.

In: International Journal of Immunopharmacology, Vol. 10, No. 3, 1988, p. 253-259.

Research output: Contribution to journalArticle

Kucharz, Eugene J. ; Sierakowski, Stanislaw ; Staite, Nigel D. ; Goodwin, James. / Mechanism of lithium-induced augmentation of T-cell proliferation. In: International Journal of Immunopharmacology. 1988 ; Vol. 10, No. 3. pp. 253-259.
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