Abstract
The mechanism whereby lithium augments mitogen-stimulated T-cell proliferation was investigated. Lithium in a concentration of 5mM caused a significant increase in interleukin 2 (IL-2) production after phytohemagglutinin (PHA) stimulation. Lithium also caused an increase in interleukin 1 production from peripheral blood monocytes. Lithium did not influence the expression of IL-2 receptors on T-cells. However, lithium did result in increased proliferative response to IL-2 in an IL-2 responsive cell line. Thus, lithium influences the T-cell proliferation response to mitogens in several ways, by stimulation of lymphokine and monokine production as well as by augmenting the response of IL-2 responsive cells to IL-2.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 253-259 |
| Number of pages | 7 |
| Journal | International Journal of Immunopharmacology |
| Volume | 10 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1988 |
| Externally published | Yes |
ASJC Scopus subject areas
- Immunology
- Pharmacology
Fingerprint
Dive into the research topics of 'Mechanism of lithium-induced augmentation of T-cell proliferation'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS