Mechanisms of bombesin on growth of gastrinoma (PT) in vivo

Kyo U. Chu, Jin Ishizuka, James F. Battey, Tatsuo Uchida, R. Daniel Beauchamp, Courtney M. Townsend, James C. Thompson

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The growth of the human gastrinoma model (PT) in athymic nude mice is stimulated by bombesin (BBS), an amphibian peptide homologous to both human gastrin-releasing peptide (GRP) and neuromedin B (NMB). The mechanism is not known, and a potent and specific GRP-R antagonist BIM26226, which has low affinity for NMB-R, was used in vivo in athymic nude mice bearing gastrinoma subcutaneously. Both the BBS and BIM26226 stimulated the growth of PT, and the growth stimulation was even greater when given together. RT-PCR study of gastrinoma revealed the presence of both GRP-R and NMB-R mRNA, but much more abundant NMB-R mRNA. We conclude that BBS-stimulated growth of gastrinoma involves both GRP-R and NMB-R, and our findings suggest that GRP-R mediates negative and NMB-R produces positive growth effects on gastrinoma.

Original languageEnglish (US)
Pages (from-to)2180-2186
Number of pages7
JournalDigestive Diseases and Sciences
Volume41
Issue number11
DOIs
StatePublished - Jan 1 1996

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Keywords

  • Bombesin
  • Gastrin
  • Gastrinoma
  • Growth

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Chu, K. U., Ishizuka, J., Battey, J. F., Uchida, T., Beauchamp, R. D., Townsend, C. M., & Thompson, J. C. (1996). Mechanisms of bombesin on growth of gastrinoma (PT) in vivo. Digestive Diseases and Sciences, 41(11), 2180-2186. https://doi.org/10.1007/BF02071398