Mechanisms of disease: The biophysical interpretation of the ECM affects physiological and pathophysiological cellular behavior

Götz Von Wichert, Michael Sheetz

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Physiological and pathophysiological migration during the development and systemic spread of tumor cells requires a highly regulated interaction with the extracellular matrix. Sensing of the physical properties of the matrix as well as of forces exerted by the cell or acting on a cell is a prerequisite for productive migration. This review focuses on current concepts of the transmission of a physical stimulus into a biochemical signal in non-neuronal cells. Moreover, we summarize the current concepts on the regulation of affinity-modulation and regulation of protein-turnover for the formation and functionality of adhesion sites with special emphasis on the role of oncogenic signal transduction pathways such as Src family kinases and focal adhesion kinase.

Original languageEnglish (US)
Pages (from-to)1329-1336
Number of pages8
JournalZeitschrift fur Gastroenterologie
Volume43
Issue number12
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

Keywords

  • Mechanotransduction
  • Metastatic disease
  • Migration

ASJC Scopus subject areas

  • Gastroenterology

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