TY - CHAP
T1 - Mechanisms of Intracellular Communication in Cancer and Pathogen Spreading
AU - Valdebenito, Silvana
AU - Ajasin, David
AU - Valerdi, Karl
AU - Liu, Yue Ran
AU - Rao, Samvrit
AU - Eugenin, Eliseo
N1 - Publisher Copyright:
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.
PY - 2024
Y1 - 2024
N2 - Cell-to-cell interactions are essential for proper development, homeostasis, and complex syncytia/organ formation and function. Intercellular communication are mediated by multiple mechanisms including soluble mediators, adhesion molecules and specific mechanisms of cell to cell communication such as Gap junctions (GJ), tunneling nanotubes (TNT), and exosomes. Only recently, has been discovered that TNTs and exosomes enable the exchange of large signaling molecules, RNA, viral products, antigens, and organelles opening new avenues of research and therapeutic approaches. The focus of this review is to summarize these recent findings in physiologic and pathologic conditions.
AB - Cell-to-cell interactions are essential for proper development, homeostasis, and complex syncytia/organ formation and function. Intercellular communication are mediated by multiple mechanisms including soluble mediators, adhesion molecules and specific mechanisms of cell to cell communication such as Gap junctions (GJ), tunneling nanotubes (TNT), and exosomes. Only recently, has been discovered that TNTs and exosomes enable the exchange of large signaling molecules, RNA, viral products, antigens, and organelles opening new avenues of research and therapeutic approaches. The focus of this review is to summarize these recent findings in physiologic and pathologic conditions.
UR - http://www.scopus.com/inward/record.url?scp=85203608408&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85203608408&partnerID=8YFLogxK
U2 - 10.1007/978-3-031-62036-2_13
DO - 10.1007/978-3-031-62036-2_13
M3 - Chapter
C2 - 39242384
AN - SCOPUS:85203608408
T3 - Results and Problems in Cell Differentiation
SP - 301
EP - 326
BT - Results and Problems in Cell Differentiation
PB - Springer Science and Business Media Deutschland GmbH
ER -