Mechanisms of Intracellular Communication in Cancer and Pathogen Spreading

Silvana Valdebenito, David Ajasin, Karl Valerdi, Yue Ran Liu, Samvrit Rao, Eliseo Eugenin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cell-to-cell interactions are essential for proper development, homeostasis, and complex syncytia/organ formation and function. Intercellular communication are mediated by multiple mechanisms including soluble mediators, adhesion molecules and specific mechanisms of cell to cell communication such as Gap junctions (GJ), tunneling nanotubes (TNT), and exosomes. Only recently, has been discovered that TNTs and exosomes enable the exchange of large signaling molecules, RNA, viral products, antigens, and organelles opening new avenues of research and therapeutic approaches. The focus of this review is to summarize these recent findings in physiologic and pathologic conditions.

Original languageEnglish (US)
Title of host publicationResults and Problems in Cell Differentiation
PublisherSpringer Science and Business Media Deutschland GmbH
Pages301-326
Number of pages26
DOIs
StatePublished - 2024

Publication series

NameResults and Problems in Cell Differentiation
Volume73
ISSN (Print)0080-1844
ISSN (Electronic)1861-0412

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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