Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder

Martina Sgritta; Sean W. Dooling; Shelly A. Buffington; Eric N. Momin; Michael B. Francis; Robert A. Britton; Mauro Costa-Mattioli

doi:10.1016/j.neuron.2018.11.018

Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder

Martina Sgritta, Sean W. Dooling, Shelly A. Buffington, Eric N. Momin, Michael B. Francis, Robert A. Britton, Mauro Costa-Mattioli

Research output: Contribution to journal › Article › peer-review

578 Scopus citations

Abstract

Precision microbial-based therapy rescues social deficits in genetic, environmental, and idiopathic mouse models of ASD. This rescue depends upon the vagus nerve as well as the oxytocinergic and dopaminergic signaling in the brain.

Original language	English (US)
Pages (from-to)	246-259.e6
Journal	Neuron
Volume	101
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2018.11.018
State	Published - Jan 16 2019

Keywords

autism
dopamine
gut-microbiota-brain axis
microbiome
oxytocin
probiotic
social behavior
vagus nerve

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/j.neuron.2018.11.018

Cite this

@article{5935118bddf24af49b018b2faec86b24,

title = "Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder",

abstract = "Precision microbial-based therapy rescues social deficits in genetic, environmental, and idiopathic mouse models of ASD. This rescue depends upon the vagus nerve as well as the oxytocinergic and dopaminergic signaling in the brain.",

keywords = "autism, dopamine, gut-microbiota-brain axis, microbiome, oxytocin, probiotic, social behavior, vagus nerve",

author = "Martina Sgritta and Dooling, {Sean W.} and Buffington, {Shelly A.} and Momin, {Eric N.} and Francis, {Michael B.} and Britton, {Robert A.} and Mauro Costa-Mattioli",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

month = jan,

day = "16",

doi = "10.1016/j.neuron.2018.11.018",

language = "English (US)",

volume = "101",

pages = "246--259.e6",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "2",

}

TY - JOUR

T1 - Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder

AU - Sgritta, Martina

AU - Dooling, Sean W.

AU - Buffington, Shelly A.

AU - Momin, Eric N.

AU - Francis, Michael B.

AU - Britton, Robert A.

AU - Costa-Mattioli, Mauro

PY - 2019/1/16

Y1 - 2019/1/16

N2 - Precision microbial-based therapy rescues social deficits in genetic, environmental, and idiopathic mouse models of ASD. This rescue depends upon the vagus nerve as well as the oxytocinergic and dopaminergic signaling in the brain.

AB - Precision microbial-based therapy rescues social deficits in genetic, environmental, and idiopathic mouse models of ASD. This rescue depends upon the vagus nerve as well as the oxytocinergic and dopaminergic signaling in the brain.

KW - autism

KW - dopamine

KW - gut-microbiota-brain axis

KW - microbiome

KW - oxytocin

KW - probiotic

KW - social behavior

KW - vagus nerve

UR - http://www.scopus.com/inward/record.url?scp=85059826502&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059826502&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2018.11.018

DO - 10.1016/j.neuron.2018.11.018

M3 - Article

C2 - 30522820

AN - SCOPUS:85059826502

SN - 0896-6273

VL - 101

SP - 246-259.e6

JO - Neuron

JF - Neuron

IS - 2

ER -

Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this