Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder

Martina Sgritta, Sean W. Dooling, Shelly Buffington, Eric N. Momin, Michael B. Francis, Robert A. Britton, Mauro Costa-Mattioli

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Precision microbial-based therapy rescues social deficits in genetic, environmental, and idiopathic mouse models of ASD. This rescue depends upon the vagus nerve as well as the oxytocinergic and dopaminergic signaling in the brain.

Original languageEnglish (US)
Pages (from-to)246-259.e6
JournalNeuron
Volume101
Issue number2
DOIs
StatePublished - Jan 16 2019
Externally publishedYes

Keywords

  • autism
  • dopamine
  • gut-microbiota-brain axis
  • microbiome
  • oxytocin
  • probiotic
  • social behavior
  • vagus nerve

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Sgritta, M., Dooling, S. W., Buffington, S., Momin, E. N., Francis, M. B., Britton, R. A., & Costa-Mattioli, M. (2019). Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder. Neuron, 101(2), 246-259.e6. https://doi.org/10.1016/j.neuron.2018.11.018