Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder

Martina Sgritta, Sean W. Dooling, Shelly Buffington, Eric N. Momin, Michael B. Francis, Robert A. Britton, Mauro Costa-Mattioli

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Precision microbial-based therapy rescues social deficits in genetic, environmental, and idiopathic mouse models of ASD. This rescue depends upon the vagus nerve as well as the oxytocinergic and dopaminergic signaling in the brain.

Original languageEnglish (US)
Pages (from-to)246-259.e6
JournalNeuron
Volume101
Issue number2
DOIs
StatePublished - Jan 16 2019
Externally publishedYes

Fingerprint

Vagus Nerve
Social Behavior
Brain
Therapeutics
Autism Spectrum Disorder

Keywords

  • autism
  • dopamine
  • gut-microbiota-brain axis
  • microbiome
  • oxytocin
  • probiotic
  • social behavior
  • vagus nerve

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sgritta, M., Dooling, S. W., Buffington, S., Momin, E. N., Francis, M. B., Britton, R. A., & Costa-Mattioli, M. (2019). Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder. Neuron, 101(2), 246-259.e6. https://doi.org/10.1016/j.neuron.2018.11.018

Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder. / Sgritta, Martina; Dooling, Sean W.; Buffington, Shelly; Momin, Eric N.; Francis, Michael B.; Britton, Robert A.; Costa-Mattioli, Mauro.

In: Neuron, Vol. 101, No. 2, 16.01.2019, p. 246-259.e6.

Research output: Contribution to journalArticle

Sgritta, M, Dooling, SW, Buffington, S, Momin, EN, Francis, MB, Britton, RA & Costa-Mattioli, M 2019, 'Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder', Neuron, vol. 101, no. 2, pp. 246-259.e6. https://doi.org/10.1016/j.neuron.2018.11.018
Sgritta, Martina ; Dooling, Sean W. ; Buffington, Shelly ; Momin, Eric N. ; Francis, Michael B. ; Britton, Robert A. ; Costa-Mattioli, Mauro. / Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder. In: Neuron. 2019 ; Vol. 101, No. 2. pp. 246-259.e6.
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