Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder

Martina Sgritta, Sean W. Dooling, Shelly A. Buffington, Eric N. Momin, Michael B. Francis, Robert A. Britton, Mauro Costa-Mattioli

    Research output: Contribution to journalArticlepeer-review

    578 Scopus citations

    Abstract

    Precision microbial-based therapy rescues social deficits in genetic, environmental, and idiopathic mouse models of ASD. This rescue depends upon the vagus nerve as well as the oxytocinergic and dopaminergic signaling in the brain.

    Original languageEnglish (US)
    Pages (from-to)246-259.e6
    JournalNeuron
    Volume101
    Issue number2
    DOIs
    StatePublished - Jan 16 2019

    Keywords

    • autism
    • dopamine
    • gut-microbiota-brain axis
    • microbiome
    • oxytocin
    • probiotic
    • social behavior
    • vagus nerve

    ASJC Scopus subject areas

    • General Neuroscience

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