Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder

Martina Sgritta; Sean W. Dooling; Shelly A. Buffington; Eric N. Momin; Michael B. Francis; Robert A. Britton; Mauro Costa-Mattioli

doi:10.1016/j.neuron.2018.11.018

Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder

Martina Sgritta, Sean W. Dooling, Shelly A. Buffington, Eric N. Momin, Michael B. Francis, Robert A. Britton, Mauro Costa-Mattioli

Neuroscience & Cell

Research output: Contribution to journal › Article › peer-review

524 Scopus citations

Abstract

Precision microbial-based therapy rescues social deficits in genetic, environmental, and idiopathic mouse models of ASD. This rescue depends upon the vagus nerve as well as the oxytocinergic and dopaminergic signaling in the brain.

Original language	English (US)
Pages (from-to)	246-259.e6
Journal	Neuron
Volume	101
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2018.11.018
State	Published - Jan 16 2019

Keywords

autism
dopamine
gut-microbiota-brain axis
microbiome
oxytocin
probiotic
social behavior
vagus nerve

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2018.11.018

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title = "Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder",

abstract = "Precision microbial-based therapy rescues social deficits in genetic, environmental, and idiopathic mouse models of ASD. This rescue depends upon the vagus nerve as well as the oxytocinergic and dopaminergic signaling in the brain.",

keywords = "autism, dopamine, gut-microbiota-brain axis, microbiome, oxytocin, probiotic, social behavior, vagus nerve",

author = "Martina Sgritta and Dooling, {Sean W.} and Buffington, {Shelly A.} and Momin, {Eric N.} and Francis, {Michael B.} and Britton, {Robert A.} and Mauro Costa-Mattioli",

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AU - Sgritta, Martina

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AU - Momin, Eric N.

AU - Francis, Michael B.

AU - Britton, Robert A.

AU - Costa-Mattioli, Mauro

PY - 2019/1/16

Y1 - 2019/1/16

N2 - Precision microbial-based therapy rescues social deficits in genetic, environmental, and idiopathic mouse models of ASD. This rescue depends upon the vagus nerve as well as the oxytocinergic and dopaminergic signaling in the brain.

AB - Precision microbial-based therapy rescues social deficits in genetic, environmental, and idiopathic mouse models of ASD. This rescue depends upon the vagus nerve as well as the oxytocinergic and dopaminergic signaling in the brain.

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KW - gut-microbiota-brain axis

KW - microbiome

KW - oxytocin

KW - probiotic

KW - social behavior

KW - vagus nerve

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Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder

Abstract

Keywords

ASJC Scopus subject areas

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