Mediators of Anaphylaxis

Yoshiko Ogawa, J. Andrew Grant

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Anaphylaxis is a life-threatening condition closely linked to IgE activation of mast cells with subsequent release of preformed mediators, including histamine, neutral proteases (tryptase and chymase), and proteoglycans (eg, heparin) from intracellular granules. These factors participate in the development of classic symptoms involving the skin, respiratory tract, circulation, and gastrointestinal system. Release of these granules is followed quickly by increased synthesis from membrane arachidonic acid of prostaglandins and leukotrienes that have an additional role in clinical symptoms. Thereafter, mast cells release numerous chemokines and cytokines that initiate recruitment and activation of additional inflammatory cells, including basophils, eosinophils, and Th2 cells.

Original languageEnglish (US)
Pages (from-to)249-260
Number of pages12
JournalImmunology and Allergy Clinics of North America
Volume27
Issue number2
DOIs
StatePublished - May 2007

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ASJC Scopus subject areas

  • Immunology and Allergy

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