Medulloblastoma with extensive nodularity: A variant occurring in the very young - Clinicopathological and immunohisotochemical study of four cases

T. N. Suresh, Vani Santosh, T. C. Yasha, B. Anandh, A. Mohanty, B. Indiradevi, S. Sampath, S. K. Shankar

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Case report: Four cases of medulloblastoma with extensive nodularity (MBEN) are described. The patients were 3 years of age or younger at diagnosis. Cranial CT scan disclosed multiple coalescing nodules with peculiar 'grape-like' architecture in three patients. A near total excision of the tumour was performed in all four patients. The patients are currently receiving radiation and chemotherapy. Histologically, the tumours were characterized by extreme nodularity with intranodular uniformity and low proliferative index. The internodular zones were extremely cellular, composed of undifferentiated, mitotically active cells. Bcl-2 protein expression was observed in the cellular zones but was distinctly absent within nodules. Discussion: MBEN represents a variant that occurs in very young children but has a good prognosis. The favourable outcome is probably related to its spontaneous neurocytic differentiation. The pattern of Bcl-2 immunoreactivity in MBENs indicates that this protein could be a key player in the regulation of neuronal differentiation in medulloblastomas.

Original languageEnglish (US)
Pages (from-to)55-60
Number of pages6
JournalChild's Nervous System
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2004
Externally publishedYes

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Keywords

  • Bcl-2 expression
  • Cerebellar neuroblastoma
  • Medulloblastoma
  • Neurocytic differentiation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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