Melatonin is a scavenger of peroxynitrite

Eli Gilad, Salvatore Cuzzocrea, Basilia Zingarelli, Andrew L. Salzman, Csaba Szabo

Research output: Contribution to journalArticle

309 Citations (Scopus)

Abstract

Peroxynitrite is a toxic oxidant formed from the reaction of superoxide and nitric oxide under conditions of inflammation and oxidant stress. Here we demonstrate that the pineal neurohormone melatonin inhibits peroxynitrite-mediated oxidant processes. Melatonin caused a dose-dependent inhibition of the oxidation of dihydrorhodamine 123 to rhodamine in vitro. Moreover, in cultured J774 macrophages, melatonin inhibited the development of DNA single strand breakage in response to peroxynitrite and reduced the suppression of mitochondrial respiration. Thus, melatonin appears to be a scavenger of peroxynitrite. This action may contribute to the antioxidant and antiinflammatory effects of melatonin in various pathophysiological conditions.

Original languageEnglish (US)
JournalLife Sciences
Volume60
Issue number10
DOIs
StatePublished - Jan 31 1997
Externally publishedYes

Fingerprint

Peroxynitrous Acid
Melatonin
Oxidants
Rhodamines
Macrophages
Poisons
Superoxides
Neurotransmitter Agents
Nitric Oxide
Respiration
Anti-Inflammatory Agents
Antioxidants
Inflammation
Oxidation
DNA

Keywords

  • Free radicals
  • Melatonin
  • Nitric oxide
  • Pineal
  • Shock

ASJC Scopus subject areas

  • Pharmacology

Cite this

Gilad, E., Cuzzocrea, S., Zingarelli, B., Salzman, A. L., & Szabo, C. (1997). Melatonin is a scavenger of peroxynitrite. Life Sciences, 60(10). https://doi.org/10.1016/S0024-3205(97)00008-8

Melatonin is a scavenger of peroxynitrite. / Gilad, Eli; Cuzzocrea, Salvatore; Zingarelli, Basilia; Salzman, Andrew L.; Szabo, Csaba.

In: Life Sciences, Vol. 60, No. 10, 31.01.1997.

Research output: Contribution to journalArticle

Gilad, E, Cuzzocrea, S, Zingarelli, B, Salzman, AL & Szabo, C 1997, 'Melatonin is a scavenger of peroxynitrite', Life Sciences, vol. 60, no. 10. https://doi.org/10.1016/S0024-3205(97)00008-8
Gilad E, Cuzzocrea S, Zingarelli B, Salzman AL, Szabo C. Melatonin is a scavenger of peroxynitrite. Life Sciences. 1997 Jan 31;60(10). https://doi.org/10.1016/S0024-3205(97)00008-8
Gilad, Eli ; Cuzzocrea, Salvatore ; Zingarelli, Basilia ; Salzman, Andrew L. ; Szabo, Csaba. / Melatonin is a scavenger of peroxynitrite. In: Life Sciences. 1997 ; Vol. 60, No. 10.
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