Melatonin relieves the neural oxidative burden that contributes to dementias

Russel J. Reiter, Dun Xian Tan, Miguel Pappolla

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

This report summarizes some of the many publications that document the beneficial actions of melatonin within the central nervous system. Of particular interest are the multiple functions of melatonin and its metabolites as ubiquitously acting direct free radical scavengers and indirect antioxidants. The fact that melatonin and the metabolic progeny that are formed when it scavenges toxic reactants are all effective in neutralizing destructive molecules greatly increases the efficacy of melatonin as a protection against by-products of oxygen and nitrogen that normally mutilate essential molecules. Of the large number of situations in which oxidative stress may be the cause of disease processes or debilitating conditions, the current review examines melatonin's protection within the central nervous system, particularly in experimental ischemia/reperfusion (stroke) injury, Alzheimer's disease, and parkinsonism. In each of these conditions, melatonin has been found to provide significant neural protection against both the morphophysiological damage and the biobehavioral consequences of these infirmities. The report concludes with the suggestion that melatonin, alone or in combination with other antioxidants, be considered for routine usage to potentially combat some of the neural ravages of aging.

Original languageEnglish (US)
Pages (from-to)179-196
Number of pages18
JournalAnnals of the New York Academy of Sciences
Volume1035
DOIs
StatePublished - 2004
Externally publishedYes

Fingerprint

Melatonin
Dementia
Neurology
Central Nervous System
Antioxidants
Free Radical Scavengers
Molecules
Oxidative stress
Poisons
Parkinsonian Disorders
Metabolites
Burden
Reperfusion Injury
Byproducts
Publications
Alzheimer Disease
Oxidative Stress
Nitrogen
Aging of materials
Stroke

Keywords

  • Alzheimer's disease
  • Free radicals
  • Ischemia/reperfusion
  • Melatonin
  • Oxidative stress
  • Parkinson's disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Melatonin relieves the neural oxidative burden that contributes to dementias. / Reiter, Russel J.; Tan, Dun Xian; Pappolla, Miguel.

In: Annals of the New York Academy of Sciences, Vol. 1035, 2004, p. 179-196.

Research output: Contribution to journalArticle

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