Membrane-initiated steroid actions and the proteins that mediate them

Cheryl S. Watson, Bahiru Gametchu

    Research output: Contribution to journalArticle

    212 Citations (Scopus)

    Abstract

    Membrane-initiated or nongenomic activities of steroids contribute to the effects of steroids on a wide variety of target organs, including those with low receptor numbers, recently discovered due to the increased sensitivity of new measurement techniques. Membrane-initiated responses are the cell's rapid and first response to steroids. The responses that emanate from the membrane can have direct functional consequences, such as secretion of other peptide hormones or rapid behavioral changes. Other rapid responses are prerequisites for subsequent genomic responses. The wide variety of signal transduction schemes employed by various tissues and hormones are summarized and discussed in terms of the identity of proteins that mediate these responses. Probable mixed binding systems for steroids in plasma membranes are compared to similar multiple hormone-binding protein systems in extracellular fluids and inside cells. These issues are related to steroid- dependent tumor growth, developmental and therapeutic apoptosis, and the actions of endocrine disrupters. The integration of membrane-initiated effects with genomic mechanisms results in the complete cellular response to steroids.

    Original languageEnglish (US)
    Pages (from-to)9-19
    Number of pages11
    JournalProceedings of the Society for Experimental Biology and Medicine
    Volume220
    Issue number1
    StatePublished - Jan 1999

    Fingerprint

    Steroids
    Membranes
    Proteins
    Endocrine disrupters
    Hormones
    Signal transduction
    Peptide Hormones
    Extracellular Fluid
    Cell membranes
    Tumors
    Signal Transduction
    Carrier Proteins
    Cell Membrane
    Tissue
    Apoptosis
    Fluids
    Growth
    Neoplasms
    Therapeutics

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Membrane-initiated steroid actions and the proteins that mediate them. / Watson, Cheryl S.; Gametchu, Bahiru.

    In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 220, No. 1, 01.1999, p. 9-19.

    Research output: Contribution to journalArticle

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