Membrane interaction and functional plasticity of inositol polyphosphate 5-phosphatases

Werner Braun, Catherine H. Schein

Research output: Contribution to journalShort survey

5 Scopus citations

Abstract

In this issue of Structure, Trésaugues and colleagues determined the interaction of membrane-bound phosphoinositides with three clinically significant human inositol polyphosphate 5-phosphatases (I5Ps). A comparison to the structures determined with soluble substrates revealed differences in the binding mode and suggested how the I5Ps and apurinic endonuclease (APE1) activities evolved from the same metal-binding active center.

Original languageEnglish (US)
Pages (from-to)664-666
Number of pages3
JournalStructure
Volume22
Issue number5
DOIs
StatePublished - May 6 2014

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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