Memory and CD8+ are the predominant bovine bronchoalveolar lymphocyte phenotypes

Jere McBride, Richard E. Corstvet, Marilyn A. Dietrich, Cindy Berry, Robert Brennan, Bernadette C. Taylor, Jeffrey L. Stott, Bennie I. Osburn

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Bovine lymphocytes obtained by bronchoalveolar lavage (BAL) of healthy calves were simultaneously analyzed and compared to peripheral blood lymphocytes using monoclonal antibodies specific for bovine leukocyte differentiation antigens. Phenotypic differences were observed between bronchoalveolar and peripheral blood T-lymphocyte subpopulations, demonstrating selective lymphocyte migration to the bovine lung. The bronchoalveolar and peripheral blood T-lymphocyte populations, defined by expression of CD2, were similar, but bronchoalveolar T lymphocytes were predominately CD8+ while peripheral blood T cells were predominately CD4+. In addition, memory lymphocytes, characterized by low expression of CD45R and activated lymphocytes (CD25+), were found in significantly higher proportions in the bronchoalveolar compartment. The proportion of γδ T lymphocytes was, however, significantly higher in peripheral blood. B cells were observed in similar proportions in the bronchoalveolar compartment and peripheral blood.

Original languageEnglish (US)
Pages (from-to)55-62
Number of pages8
JournalVeterinary Immunology and Immunopathology
Volume58
Issue number1
DOIs
StatePublished - Aug 1997
Externally publishedYes

Fingerprint

lymphocytes
T-lymphocytes
Lymphocytes
T-Lymphocytes
Phenotype
phenotype
cattle
blood
CD antigens
Differentiation Antigens
Lymphocyte Subsets
Bronchoalveolar Lavage
blood cells
HLA Antigens
B-lymphocytes
monoclonal antibodies
Blood Cells
B-Lymphocytes
lungs
Monoclonal Antibodies

Keywords

  • Bovine
  • Bronchoalveolar lavage
  • Lung
  • Lymphocytes
  • Pasteurella
  • Respiratory disease

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Immunology
  • veterinary(all)

Cite this

McBride, J., Corstvet, R. E., Dietrich, M. A., Berry, C., Brennan, R., Taylor, B. C., ... Osburn, B. I. (1997). Memory and CD8+ are the predominant bovine bronchoalveolar lymphocyte phenotypes. Veterinary Immunology and Immunopathology, 58(1), 55-62. https://doi.org/10.1016/S0165-2427(96)05777-7

Memory and CD8+ are the predominant bovine bronchoalveolar lymphocyte phenotypes. / McBride, Jere; Corstvet, Richard E.; Dietrich, Marilyn A.; Berry, Cindy; Brennan, Robert; Taylor, Bernadette C.; Stott, Jeffrey L.; Osburn, Bennie I.

In: Veterinary Immunology and Immunopathology, Vol. 58, No. 1, 08.1997, p. 55-62.

Research output: Contribution to journalArticle

McBride, J, Corstvet, RE, Dietrich, MA, Berry, C, Brennan, R, Taylor, BC, Stott, JL & Osburn, BI 1997, 'Memory and CD8+ are the predominant bovine bronchoalveolar lymphocyte phenotypes', Veterinary Immunology and Immunopathology, vol. 58, no. 1, pp. 55-62. https://doi.org/10.1016/S0165-2427(96)05777-7
McBride, Jere ; Corstvet, Richard E. ; Dietrich, Marilyn A. ; Berry, Cindy ; Brennan, Robert ; Taylor, Bernadette C. ; Stott, Jeffrey L. ; Osburn, Bennie I. / Memory and CD8+ are the predominant bovine bronchoalveolar lymphocyte phenotypes. In: Veterinary Immunology and Immunopathology. 1997 ; Vol. 58, No. 1. pp. 55-62.
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abstract = "Bovine lymphocytes obtained by bronchoalveolar lavage (BAL) of healthy calves were simultaneously analyzed and compared to peripheral blood lymphocytes using monoclonal antibodies specific for bovine leukocyte differentiation antigens. Phenotypic differences were observed between bronchoalveolar and peripheral blood T-lymphocyte subpopulations, demonstrating selective lymphocyte migration to the bovine lung. The bronchoalveolar and peripheral blood T-lymphocyte populations, defined by expression of CD2, were similar, but bronchoalveolar T lymphocytes were predominately CD8+ while peripheral blood T cells were predominately CD4+. In addition, memory lymphocytes, characterized by low expression of CD45R and activated lymphocytes (CD25+), were found in significantly higher proportions in the bronchoalveolar compartment. The proportion of γδ T lymphocytes was, however, significantly higher in peripheral blood. B cells were observed in similar proportions in the bronchoalveolar compartment and peripheral blood.",
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