Memory T cells in flavivirus vaccination

Guangyu Li, Cody Teleki, Tian Wang

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Flaviviruses include many medically important viruses, such as Dengue virus (DENV), Japanese encephalitis (JEV), tick-borne encephalitis (TBEV), West Nile (WNV), yellow fever (YFV), and Zika viruses (ZIKV). Currently, there are licensed human vaccines for DENV, JEV, TBEV and YFV, but not for WNV or ZIKV. Memory T cells play a central role in adaptive immunity and are important for host protection during flavivirus infection. In this review, we discuss recent findings from animal models and clinical trials and provide new insights into the role of memory T cells in host protective immunity upon vaccination with the licensed flavivirus vaccines.

Original languageEnglish (US)
Article number73
JournalVaccines
Volume6
Issue number4
DOIs
StatePublished - Dec 1 2018

    Fingerprint

Keywords

  • Flavivirus
  • Memory T cells
  • Vaccine

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Drug Discovery
  • Infectious Diseases
  • Pharmacology (medical)

Cite this