Memory T cells in flavivirus vaccination

Guangyu Li; Cody Teleki; Tian Wang

doi:10.3390/vaccines6040073

Memory T cells in flavivirus vaccination

Guangyu Li, Cody Teleki, Tian Wang

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Flaviviruses include many medically important viruses, such as Dengue virus (DENV), Japanese encephalitis (JEV), tick-borne encephalitis (TBEV), West Nile (WNV), yellow fever (YFV), and Zika viruses (ZIKV). Currently, there are licensed human vaccines for DENV, JEV, TBEV and YFV, but not for WNV or ZIKV. Memory T cells play a central role in adaptive immunity and are important for host protection during flavivirus infection. In this review, we discuss recent findings from animal models and clinical trials and provide new insights into the role of memory T cells in host protective immunity upon vaccination with the licensed flavivirus vaccines.

Original language	English (US)
Article number	73
Journal	Vaccines
Volume	6
Issue number	4
DOIs	https://doi.org/10.3390/vaccines6040073
State	Published - Dec 2018

Keywords

Flavivirus
Memory T cells
Vaccine

ASJC Scopus subject areas

Immunology
Pharmacology
Drug Discovery
Infectious Diseases
Pharmacology (medical)

Access to Document

10.3390/vaccines6040073

Cite this

@article{d38620ffcbf846a4bf2ad495ec5277a9,

title = "Memory T cells in flavivirus vaccination",

abstract = "Flaviviruses include many medically important viruses, such as Dengue virus (DENV), Japanese encephalitis (JEV), tick-borne encephalitis (TBEV), West Nile (WNV), yellow fever (YFV), and Zika viruses (ZIKV). Currently, there are licensed human vaccines for DENV, JEV, TBEV and YFV, but not for WNV or ZIKV. Memory T cells play a central role in adaptive immunity and are important for host protection during flavivirus infection. In this review, we discuss recent findings from animal models and clinical trials and provide new insights into the role of memory T cells in host protective immunity upon vaccination with the licensed flavivirus vaccines.",

keywords = "Flavivirus, Memory T cells, Vaccine",

author = "Guangyu Li and Cody Teleki and Tian Wang",

note = "Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2018",

month = dec,

doi = "10.3390/vaccines6040073",

language = "English (US)",

volume = "6",

journal = "Vaccines",

issn = "2076-393X",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "4",

}

TY - JOUR

T1 - Memory T cells in flavivirus vaccination

AU - Li, Guangyu

AU - Teleki, Cody

AU - Wang, Tian

PY - 2018/12

Y1 - 2018/12

N2 - Flaviviruses include many medically important viruses, such as Dengue virus (DENV), Japanese encephalitis (JEV), tick-borne encephalitis (TBEV), West Nile (WNV), yellow fever (YFV), and Zika viruses (ZIKV). Currently, there are licensed human vaccines for DENV, JEV, TBEV and YFV, but not for WNV or ZIKV. Memory T cells play a central role in adaptive immunity and are important for host protection during flavivirus infection. In this review, we discuss recent findings from animal models and clinical trials and provide new insights into the role of memory T cells in host protective immunity upon vaccination with the licensed flavivirus vaccines.

AB - Flaviviruses include many medically important viruses, such as Dengue virus (DENV), Japanese encephalitis (JEV), tick-borne encephalitis (TBEV), West Nile (WNV), yellow fever (YFV), and Zika viruses (ZIKV). Currently, there are licensed human vaccines for DENV, JEV, TBEV and YFV, but not for WNV or ZIKV. Memory T cells play a central role in adaptive immunity and are important for host protection during flavivirus infection. In this review, we discuss recent findings from animal models and clinical trials and provide new insights into the role of memory T cells in host protective immunity upon vaccination with the licensed flavivirus vaccines.

KW - Flavivirus

KW - Memory T cells

KW - Vaccine

UR - https://www.scopus.com/pages/publications/85055820872

UR - https://www.scopus.com/inward/citedby.url?scp=85055820872&partnerID=8YFLogxK

U2 - 10.3390/vaccines6040073

DO - 10.3390/vaccines6040073

M3 - Article

C2 - 30340377

AN - SCOPUS:85055820872

SN - 2076-393X

VL - 6

JO - Vaccines

JF - Vaccines

IS - 4

M1 - 73

ER -

Memory T cells in flavivirus vaccination

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this