Menopausal hormone therapy and change in physical activity in the Women's Health Initiative hormone therapy clinical trials

Rita Peila, Xiaonan Xue, Michael J. Lamonte, Aladdin H. Shadyab, Jean Wactawski-Wende, Su Yon Jung, Karen C. Johnson, Mace Coday, Phyllis Richey, Charles P. Mouton, Nazums Saquib, Rowan T. Chlebowski, Kathy Pan, Yvonne L. Michael, Meryl S. Leboff, Jo Ann E. Manson, Thomas E. Rohan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective The menopausal transition results in a progressive decrease in circulating estrogen levels. Experimental evidence in rodents has indicated that estrogen depletion leads to a reduction of energy expenditure and physical activity. It is unclear whether treatment with estrogen therapy increases physical activity level in postmenopausal women. Methods A total of 27,327 postmenopausal women aged 50-79 years enrolled in the Women's Health Initiative randomized double-blind trials of menopausal hormone therapy. Self-reported leisure-time physical activity at baseline, and years 1, 3, and 6 was quantified as metabolic equivalents (MET)-h/wk. In each trial, comparison between intervention and placebo groups of changes in physical activity levels from baseline to follow-up assessment was examined using linear regression models. Results In the CEE-alone trial, the increase in MET-h/wk was greater in the placebo group compared with the intervention group at years 3 (P = 0.002) and 6 (P < 0.001). Similar results were observed when analyses were restricted to women who maintained an adherence rate ≥80% during the trial or who were physically active at baseline. In the CEE + MPA trial, the primary analyses did not show significant differences between groups, but the increase of MET-h/wk was greater in the placebo group compared with the intervention group at year 3 (P = 0.004) among women with an adherence rate ≥80%. Conclusions The results from this clinical trial do not support the hypothesis that estrogen treatment increases physical activity among postmenopausal women.

Original languageEnglish (US)
Pages (from-to)898-905
Number of pages8
JournalMenopause
Volume30
Issue number9
DOIs
StatePublished - Sep 2023
Externally publishedYes

Keywords

  • Hormone therapy
  • Physical activity
  • Postmenopause

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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