Mesenchymal cells of the intestinal lamina propria

D. W. Powell, Iryna Pinchuk, J. I. Saada, Xin Chen, R. C. Mifflin

Research output: Contribution to journalArticle

174 Citations (Scopus)

Abstract

The mesenchymal elements of the intestinal lamina propria reviewed here are the myofibroblasts, fibroblasts, mural cells (pericytes) of the vasculature, bone marrow derived stromal stem cells, smooth muscle of the muscularis mucosae, and smooth muscle surrounding the lymphatic lacteals. These cells share similar marker molecules, origins, and coordinated biological functions previously ascribed solely to subepithelial myofibroblasts. We review the functional anatomy of intestinal mesenchymal cells and describe what is known about their origin in the embryo and their replacement in adults. As part of their putative role in intestinal mucosal morphogenesis, we consider the intestinal stem cell niche. Lastly, we review emerging information about myofibroblasts as nonprofessional immune cells that may be important as an alarm system for the gut and as a participant in peripheral immune tolerance.

Original languageEnglish (US)
Pages (from-to)213-237
Number of pages25
JournalAnnual Review of Physiology
Volume73
DOIs
StatePublished - 2011

Fingerprint

Myofibroblasts
Mucous Membrane
Smooth Muscle
Peripheral Tolerance
Stem Cell Niche
Immune Tolerance
Pericytes
Stromal Cells
Morphogenesis
Anatomy
Milk
Stem Cells
Embryonic Structures
Fibroblasts
Bone Marrow

Keywords

  • colorectal cancer
  • mucosal immunology
  • muscularis mucosae
  • myofibroblast
  • stem cell niche

ASJC Scopus subject areas

  • Physiology

Cite this

Powell, D. W., Pinchuk, I., Saada, J. I., Chen, X., & Mifflin, R. C. (2011). Mesenchymal cells of the intestinal lamina propria. Annual Review of Physiology, 73, 213-237. https://doi.org/10.1146/annurev.physiol.70.113006.100646

Mesenchymal cells of the intestinal lamina propria. / Powell, D. W.; Pinchuk, Iryna; Saada, J. I.; Chen, Xin; Mifflin, R. C.

In: Annual Review of Physiology, Vol. 73, 2011, p. 213-237.

Research output: Contribution to journalArticle

Powell, DW, Pinchuk, I, Saada, JI, Chen, X & Mifflin, RC 2011, 'Mesenchymal cells of the intestinal lamina propria', Annual Review of Physiology, vol. 73, pp. 213-237. https://doi.org/10.1146/annurev.physiol.70.113006.100646
Powell, D. W. ; Pinchuk, Iryna ; Saada, J. I. ; Chen, Xin ; Mifflin, R. C. / Mesenchymal cells of the intestinal lamina propria. In: Annual Review of Physiology. 2011 ; Vol. 73. pp. 213-237.
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