Mesenteric lymphadenectomy prevents postburn systemic spread of translocated bacteria

R. Tokyay, S. T. Zeigler, H. M. Loick, J. P. Heggers, P. De la Garza, D. L. Traber, David Herndon

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We investigated the role of mesenteric lymph nodes in postburn systemic spread of intestinal bacteria. Group 1 minipigs (n = 8) had a 40% third- degree burn. Group 2 minipigs (n = 7) had the same burn injury, but their mesenteric lymph nodes were removed immediately after burn. Group 3 minipigs (n = 8) had sham burn, and group 4 minipigs (n = 6) had mesenteric lymph node removal under anesthesia. All minipigs were killed at 48 hours, and tissues were harvested for bacteriological culture. Group 1 showed a large number of positive cultures from several of the systemic organs. Group 2 demonstrated no positive cultures in any of the tissues except the peritoneal fluid. These data suggest that bacterial translocation occurs mainly via mesenteric lymphatics to mesenteric lymph nodes and, thence, into other systemic tissue. After major burns, mesenteric lymph nodes may become an additional focus of infection.

Original languageEnglish (US)
Pages (from-to)384-388
Number of pages5
JournalArchives of Surgery
Volume127
Issue number4
StatePublished - 1992

Fingerprint

Miniature Swine
Lymph Node Excision
Lymph Nodes
Bacteria
Bacterial Translocation
Ascitic Fluid
Burns
Anesthesia
Wounds and Injuries
Infection

ASJC Scopus subject areas

  • Surgery

Cite this

Tokyay, R., Zeigler, S. T., Loick, H. M., Heggers, J. P., De la Garza, P., Traber, D. L., & Herndon, D. (1992). Mesenteric lymphadenectomy prevents postburn systemic spread of translocated bacteria. Archives of Surgery, 127(4), 384-388.

Mesenteric lymphadenectomy prevents postburn systemic spread of translocated bacteria. / Tokyay, R.; Zeigler, S. T.; Loick, H. M.; Heggers, J. P.; De la Garza, P.; Traber, D. L.; Herndon, David.

In: Archives of Surgery, Vol. 127, No. 4, 1992, p. 384-388.

Research output: Contribution to journalArticle

Tokyay, R, Zeigler, ST, Loick, HM, Heggers, JP, De la Garza, P, Traber, DL & Herndon, D 1992, 'Mesenteric lymphadenectomy prevents postburn systemic spread of translocated bacteria', Archives of Surgery, vol. 127, no. 4, pp. 384-388.
Tokyay R, Zeigler ST, Loick HM, Heggers JP, De la Garza P, Traber DL et al. Mesenteric lymphadenectomy prevents postburn systemic spread of translocated bacteria. Archives of Surgery. 1992;127(4):384-388.
Tokyay, R. ; Zeigler, S. T. ; Loick, H. M. ; Heggers, J. P. ; De la Garza, P. ; Traber, D. L. ; Herndon, David. / Mesenteric lymphadenectomy prevents postburn systemic spread of translocated bacteria. In: Archives of Surgery. 1992 ; Vol. 127, No. 4. pp. 384-388.
@article{37a508d35c094e67804b4766eac6e8f7,
title = "Mesenteric lymphadenectomy prevents postburn systemic spread of translocated bacteria",
abstract = "We investigated the role of mesenteric lymph nodes in postburn systemic spread of intestinal bacteria. Group 1 minipigs (n = 8) had a 40{\%} third- degree burn. Group 2 minipigs (n = 7) had the same burn injury, but their mesenteric lymph nodes were removed immediately after burn. Group 3 minipigs (n = 8) had sham burn, and group 4 minipigs (n = 6) had mesenteric lymph node removal under anesthesia. All minipigs were killed at 48 hours, and tissues were harvested for bacteriological culture. Group 1 showed a large number of positive cultures from several of the systemic organs. Group 2 demonstrated no positive cultures in any of the tissues except the peritoneal fluid. These data suggest that bacterial translocation occurs mainly via mesenteric lymphatics to mesenteric lymph nodes and, thence, into other systemic tissue. After major burns, mesenteric lymph nodes may become an additional focus of infection.",
author = "R. Tokyay and Zeigler, {S. T.} and Loick, {H. M.} and Heggers, {J. P.} and {De la Garza}, P. and Traber, {D. L.} and David Herndon",
year = "1992",
language = "English (US)",
volume = "127",
pages = "384--388",
journal = "JAMA Surgery",
issn = "2168-6254",
publisher = "American Medical Association",
number = "4",

}

TY - JOUR

T1 - Mesenteric lymphadenectomy prevents postburn systemic spread of translocated bacteria

AU - Tokyay, R.

AU - Zeigler, S. T.

AU - Loick, H. M.

AU - Heggers, J. P.

AU - De la Garza, P.

AU - Traber, D. L.

AU - Herndon, David

PY - 1992

Y1 - 1992

N2 - We investigated the role of mesenteric lymph nodes in postburn systemic spread of intestinal bacteria. Group 1 minipigs (n = 8) had a 40% third- degree burn. Group 2 minipigs (n = 7) had the same burn injury, but their mesenteric lymph nodes were removed immediately after burn. Group 3 minipigs (n = 8) had sham burn, and group 4 minipigs (n = 6) had mesenteric lymph node removal under anesthesia. All minipigs were killed at 48 hours, and tissues were harvested for bacteriological culture. Group 1 showed a large number of positive cultures from several of the systemic organs. Group 2 demonstrated no positive cultures in any of the tissues except the peritoneal fluid. These data suggest that bacterial translocation occurs mainly via mesenteric lymphatics to mesenteric lymph nodes and, thence, into other systemic tissue. After major burns, mesenteric lymph nodes may become an additional focus of infection.

AB - We investigated the role of mesenteric lymph nodes in postburn systemic spread of intestinal bacteria. Group 1 minipigs (n = 8) had a 40% third- degree burn. Group 2 minipigs (n = 7) had the same burn injury, but their mesenteric lymph nodes were removed immediately after burn. Group 3 minipigs (n = 8) had sham burn, and group 4 minipigs (n = 6) had mesenteric lymph node removal under anesthesia. All minipigs were killed at 48 hours, and tissues were harvested for bacteriological culture. Group 1 showed a large number of positive cultures from several of the systemic organs. Group 2 demonstrated no positive cultures in any of the tissues except the peritoneal fluid. These data suggest that bacterial translocation occurs mainly via mesenteric lymphatics to mesenteric lymph nodes and, thence, into other systemic tissue. After major burns, mesenteric lymph nodes may become an additional focus of infection.

UR - http://www.scopus.com/inward/record.url?scp=0026579259&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026579259&partnerID=8YFLogxK

M3 - Article

VL - 127

SP - 384

EP - 388

JO - JAMA Surgery

JF - JAMA Surgery

SN - 2168-6254

IS - 4

ER -