Mesoscopic p53-rich clusters represent a new class of protein condensates

Keyphrases

• Mesoscopic 100%
• Protein Condensates 100%
• Protein Domain 66%
• Amyloid Fibrils 66%
• Amyloid Fibrillation 66%
• TP53 mutation 66%
• Oncogenicity 66%
• Protein-rich Clusters 66%
• Tumor Suppressor 33%
• P53 Protein 33%
• N-terminus 33%
• Breast Cancer Cells 33%
• Fibrillization 33%
• Wild-type p53 33%
• Unique Proteins 33%
• Mutant p53 33%
• Disordered Regions 33%
• Condensation 33%
• Oncogenic mutations 33%
• P53 Aggregation 33%
• Dense Liquid 33%
• DBD Domain 33%
• TEM Imaging 33%
• Narrow Size Distribution 33%
• Cytosol 33%
• Ordered Proteins 33%
• Oncogenic Function 33%
• Mesoscale Clusters 33%
• Cancer Promotor 33%
• Structured Domains 33%
• Ordered Domains 33%

Biochemistry, Genetics and Molecular Biology

• P53 100%
• Amyloid Protein 30%
• Carcinogenesis 20%
• Protein Tertiary Structure 20%
• Transcription 10%
• Promoter Region 10%
• Wild Type 10%
• Tumor Suppressor Protein 10%
• Cancer Cell 10%
• N-Terminus 10%
• Transmission Electron Microscopy 10%