Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils

Keyphrases

• Amyloid Fibrils 100%
• Mutant p53 100%
• Mesoscopic 100%
• Protein-rich Clusters 100%
• Biological Function 33%
• Tumor Suppressor 33%
• Cancer Cells 33%
• Confocal Microscopy 33%
• In Cancer 33%
• Immunofluorescence 33%
• Light Scattering 33%
• Three-dimensional (3D) 33%
• Biological Systems 33%
• Arginine 33%
• Molecular Simulation 33%
• Purified Proteins 33%
• Glutamine 33%
• Associated Pathologies 33%
• Guardian 33%
• Fibrillization 33%
• Transmission Electron Microscopy 33%
• Human Breast Cancer Cells 33%
• Unique Properties 33%
• Light Transmission 33%
• P53 mutant 33%
• Unstructured Regions 33%
• Protein Phases 33%
• Cluster Size 33%
• Physicochemical Mechanisms 33%
• Protein p53 33%
• Phase Transformation Mechanism 33%
• Protein Simulation 33%
• Multiple Length Scales 33%
• Partially Disordered Proteins 33%
• Dense Liquid 33%
• Protein Condensates 33%
• Solution Concentration 33%
• Two-step nucleation 33%
• Clustering Features 33%

Biochemistry, Genetics and Molecular Biology

• P53 100%
• Amyloid 100%
• Nucleation 100%
• Solution and Solubility 37%
• Cancer Cell 25%
• Promoter Region 12%
• Biological Functions 12%
• Tumor Suppressor Protein 12%
• Confocal Microscopy 12%
• Immunofluorescence 12%
• Light Scattering 12%
• Glutamine 12%
• Arginine 12%
• Transmission Electron Microscopy 12%