Messenger RNA reprogramming by spliceosome-mediated RNA trans-splicing

Mariano A. Garcia-Blanco

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations


In the human genome, the majority of protein-encoding genes are interrupted by introns, which are removed from primary transcripts by a macromolecular enzyme known as the spliceosome. Spliceosomes can constitutively remove all the introns in a primary transcript to yield a fully spliced mRNA or alternatively splice primary transcripts leading to the production of many different mRNAs from one gene. This review examines how spliceosomes can recombine two primary transcripts in trans to reprogram messenger RNAs.

Original languageEnglish (US)
Pages (from-to)474-480
Number of pages7
JournalJournal of Clinical Investigation
Issue number4
StatePublished - Aug 2003
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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