Abstract
Objective: The objective of this study is to explore the sinopulmonary outcomes of aspirin desensitization through a systematic review and meta-analysis. Data Sources: Embase and OVID Medline databases. Review Methods: A systematic review of published articles on outcomes following aspirin desensitization in any language for relevant articles was performed in February 2019. Outcomes included sinonasal quality-of-life assessment, sense-of-smell scores, FEV-1 (forced expiratory volume in 1 second), and medication/steroid use. Results: Thirteen studies met the inclusion criteria out of 6055 articles screened. Aspirin desensitization resulted in significant improvement in FEV-1 and reduction in asthma medication/steroid use (P <.05). There was no significant improvement in the sinonasal quality of life of patients who underwent aspirin desensitization (P =.098). Conclusion: Aspirin desensitization appears to be effective in improving pulmonary outcomes and should be considered in the treatment of patients with aspirin-exacerbated respiratory disease. However, good-quality studies are still needed to determine the ideal protocol tailored to individual patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11-18 |
| Number of pages | 8 |
| Journal | Otolaryngology - Head and Neck Surgery (United States) |
| Volume | 164 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2021 |
Keywords
- AERD
- ATA (aspirin-tolerant asthma)
- NSAID
- SNOT-22
- Samter’s triad
- Sino-Nasal Outcome Test)
- acetylsalicylic acid
- aspirin-induced asthma
- aspirin-tolerant asthma
- humans
- immunologic
- nonsteroidal anti-inflammatory drug
- oral aspirin desensitization
- respiration disorders
ASJC Scopus subject areas
- Surgery
- Otorhinolaryngology