Meta-analysis Exploring Sinopulmonary Outcomes of Aspirin Desensitization in Aspirin-Exacerbated Respiratory Disease

Mohamad R. Chaaban, David Moffatt, Alex E. Wright, James A. Cowthran, En Shuo Hsu, Yong Fang Kuo

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Objective: The objective of this study is to explore the sinopulmonary outcomes of aspirin desensitization through a systematic review and meta-analysis. Data Sources: Embase and OVID Medline databases. Review Methods: A systematic review of published articles on outcomes following aspirin desensitization in any language for relevant articles was performed in February 2019. Outcomes included sinonasal quality-of-life assessment, sense-of-smell scores, FEV-1 (forced expiratory volume in 1 second), and medication/steroid use. Results: Thirteen studies met the inclusion criteria out of 6055 articles screened. Aspirin desensitization resulted in significant improvement in FEV-1 and reduction in asthma medication/steroid use (P <.05). There was no significant improvement in the sinonasal quality of life of patients who underwent aspirin desensitization (P =.098). Conclusion: Aspirin desensitization appears to be effective in improving pulmonary outcomes and should be considered in the treatment of patients with aspirin-exacerbated respiratory disease. However, good-quality studies are still needed to determine the ideal protocol tailored to individual patients.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalOtolaryngology - Head and Neck Surgery (United States)
Issue number1
StatePublished - Jan 2021


  • AERD
  • ATA (aspirin-tolerant asthma)
  • SNOT-22
  • Samter’s triad
  • Sino-Nasal Outcome Test)
  • acetylsalicylic acid
  • aspirin-induced asthma
  • aspirin-tolerant asthma
  • humans
  • immunologic
  • nonsteroidal anti-inflammatory drug
  • oral aspirin desensitization
  • respiration disorders

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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