Meta-analysis of the clinical and laboratory parameters of SFTS patients in China

Miao Miao Liu, Xiao Ying Lei, Xue Jie Yu

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever in East Asia, which is caused by a novel bunyavirus-SFTSV. Many studies have reported the clinical characters of SFTS patients, but the reports were not consistent and a systematic summary of clinical manifestations and laboratory parameters are not available. Method: A comprehensive literature research of Web of Science, PubMed, Wan Fang Data, and Chinese National Knowledge Infrastructure databases was conducted on articles which have described the clinical characters of SFTS patients. Data from selected studies were pooled by using STATA VERSION 12.0 software. Result: Nine articles comprising 844 laboratory-confirmed SFTSV cases were included in this meta-analysis. The pooled case fatality rate was 16% (95% CI: 0.13-0.19). The major clinical characters of patients with SFTSV infection were fever, thrombocytopenia, leucopenia, gastrointestinal symptoms, and central nervous system manifestations. The risk factors for severe disease included bleeding tendency, central nervous system manifestations, elevated serum enzymes, and high viral load. Although there is no specific antiviral therapy for SFTSV infection, symptomatic treatment and supportive therapy including intensive monitoring is the most essential part of case management. Conclusion: The major clinical characters of patients with SFTSV infection were fever, thrombocytopenia, leucopenia and gastrointestinal symptoms, and central nervous system manifestations. The risk factors for severity and fatality among SFTS patients included: old age, CNS manifestations, bleeding tendency, elevated serum enzymes, and high vial load.

Original languageEnglish (US)
Article number198
JournalVirology Journal
Volume13
Issue number1
DOIs
StatePublished - Nov 29 2016

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Keywords

  • Case fatality rate
  • Clinical manifestation
  • Risk factor
  • Severe fever with thrombocytopenia syndrome (SFTS)

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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