Metabolic abnormalities of mitochondrial redox potential in postburn multiple system organ failure

Y. L. Dong, C. Y. Sheng, D. N. Herndon, J. P. Waymack

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Forty-five burn patients underwent sequential assays for plasma acetoacetate and beta-hydroxybutyrate concentrations as well as plasma amino acid levels. Those patients who went on to develop multiple system organ failure were noted to have a decrease in their acetoacetate concentration with time, whereas there was no change in those patients who failed to develop multiple system organ failure. The plasma concentration of beta-hydroxybutyrate was not altered by multiple system organ failure. In addition, the plasma acetoacetate/beta-hydroxybutyrate ratio was found to be directly related to the plasma concentration of branched chain amino acids and inversely related to the concentration of aromatic amino acids.

Original languageEnglish (US)
Pages (from-to)283-286
Number of pages4
JournalBurns
Volume18
Issue number4
DOIs
StatePublished - Aug 1992

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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