Metabolic activation and biological effects of nitrosamines in the mammalian lung

Hildegrand M. Schulle, Miriam Falzon, James B. McMahon

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Nitrosamines and their precursors are among the most common contaminants of our environment, and may of therm are highly carcinogenic. Nitrosamines are believed to require metabolic activation in the host organism, and many of them demonstrate a pronounced organ and cell type specificity. This review summarizes recent in vivo and in vitro experiments which focus on the mechanisms of nitrosamine-induced lung carcinogenesis. Currently available in vivo and in vitro data suggest that nitrosamines may be metabolized by cytochrome P-450, prostaglandin endoperoxide synthetase, or monoamine oxidases. The presence of one or the other of these enzyme systems may be partially responsible for the cell type-specific effects of this class of chemicals. Moreover, evidence in vitro suggests selective uptake of nitrosamines by cell type-specific receptors, a phenomenon which offers a more logical explanation than previously published theories for the selectively of biological effects exerted by nitrosamines.

Original languageEnglish (US)
Pages (from-to)95-103
Number of pages9
JournalPharmacology and Therapeutics
Volume46
Issue number1
DOIs
StatePublished - 1990
Externally publishedYes

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Nitrosamines
Lung
Organ Specificity
Monoamine Oxidase
Prostaglandin-Endoperoxide Synthases
Cytochrome P-450 Enzyme System
Metabolic Activation
Carcinogenesis
Enzymes
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology

Cite this

Metabolic activation and biological effects of nitrosamines in the mammalian lung. / Schulle, Hildegrand M.; Falzon, Miriam; McMahon, James B.

In: Pharmacology and Therapeutics, Vol. 46, No. 1, 1990, p. 95-103.

Research output: Contribution to journalArticle

Schulle, Hildegrand M. ; Falzon, Miriam ; McMahon, James B. / Metabolic activation and biological effects of nitrosamines in the mammalian lung. In: Pharmacology and Therapeutics. 1990 ; Vol. 46, No. 1. pp. 95-103.
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