Metabolic and Endocrine Considerations After Burn Injury

Felicia N. Williams, David Herndon

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Severe burn injury is followed by a profound hypermetabolic response that persists up to 2 years after injury. It is mediated by up to 50-fold elevations in plasma catecholamines, cortisol, and glucagon that lead to whole-body catabolism, elevated resting energy expenditures, and multiorgan dysfunction. Modulation of the response by early excision and grafting of burn wounds, thermoregulation, control of infection, early and continuous enteral nutrition, and pharmacologic treatments aimed at mitigating physiologic derangements have markedly decreased morbidity.

Original languageEnglish (US)
JournalClinics in Plastic Surgery
DOIs
StateAccepted/In press - 2017

Fingerprint

Wounds and Injuries
Body Temperature Regulation
Enteral Nutrition
Infection Control
Glucagon
Energy Metabolism
Catecholamines
Hydrocortisone
Morbidity
Therapeutics

Keywords

  • Catecholamines
  • Hypercatabolism
  • Hypermetabolism
  • Insulin resistance
  • Nutrition
  • Oxandrolone
  • Propranolol

ASJC Scopus subject areas

  • Surgery

Cite this

Metabolic and Endocrine Considerations After Burn Injury. / Williams, Felicia N.; Herndon, David.

In: Clinics in Plastic Surgery, 2017.

Research output: Contribution to journalArticle

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