Metabolic and Endocrine Considerations After Burn Injury

Felicia N. Williams, David Herndon

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Severe burn injury is followed by a profound hypermetabolic response that persists up to 2 years after injury. It is mediated by up to 50-fold elevations in plasma catecholamines, cortisol, and glucagon that lead to whole-body catabolism, elevated resting energy expenditures, and multiorgan dysfunction. Modulation of the response by early excision and grafting of burn wounds, thermoregulation, control of infection, early and continuous enteral nutrition, and pharmacologic treatments aimed at mitigating physiologic derangements have markedly decreased morbidity.

Original languageEnglish (US)
JournalClinics in Plastic Surgery
DOIs
StateAccepted/In press - 2017

Keywords

  • Catecholamines
  • Hypercatabolism
  • Hypermetabolism
  • Insulin resistance
  • Nutrition
  • Oxandrolone
  • Propranolol

ASJC Scopus subject areas

  • Surgery

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