Metabolic and Endocrine Considerations After Burn Injury

Felicia N. Williams; David N. Herndon

doi:10.1016/j.cps.2017.02.013

Metabolic and Endocrine Considerations After Burn Injury

Felicia N. Williams, David N. Herndon

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

Severe burn injury is followed by a profound hypermetabolic response that persists up to 2 years after injury. It is mediated by up to 50-fold elevations in plasma catecholamines, cortisol, and glucagon that lead to whole-body catabolism, elevated resting energy expenditures, and multiorgan dysfunction. Modulation of the response by early excision and grafting of burn wounds, thermoregulation, control of infection, early and continuous enteral nutrition, and pharmacologic treatments aimed at mitigating physiologic derangements have markedly decreased morbidity.

Original language	English (US)
Pages (from-to)	541-553
Number of pages	13
Journal	Clinics in Plastic Surgery
Volume	44
Issue number	3
DOIs	https://doi.org/10.1016/j.cps.2017.02.013
State	Published - Jul 2017
Externally published	Yes

Keywords

Catecholamines
Hypercatabolism
Hypermetabolism
Insulin resistance
Nutrition
Oxandrolone
Propranolol

ASJC Scopus subject areas

Surgery

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10.1016/j.cps.2017.02.013

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title = "Metabolic and Endocrine Considerations After Burn Injury",

abstract = "Severe burn injury is followed by a profound hypermetabolic response that persists up to 2 years after injury. It is mediated by up to 50-fold elevations in plasma catecholamines, cortisol, and glucagon that lead to whole-body catabolism, elevated resting energy expenditures, and multiorgan dysfunction. Modulation of the response by early excision and grafting of burn wounds, thermoregulation, control of infection, early and continuous enteral nutrition, and pharmacologic treatments aimed at mitigating physiologic derangements have markedly decreased morbidity.",

keywords = "Catecholamines, Hypercatabolism, Hypermetabolism, Insulin resistance, Nutrition, Oxandrolone, Propranolol",

author = "Williams, {Felicia N.} and Herndon, {David N.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

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AU - Williams, Felicia N.

AU - Herndon, David N.

PY - 2017/7

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N2 - Severe burn injury is followed by a profound hypermetabolic response that persists up to 2 years after injury. It is mediated by up to 50-fold elevations in plasma catecholamines, cortisol, and glucagon that lead to whole-body catabolism, elevated resting energy expenditures, and multiorgan dysfunction. Modulation of the response by early excision and grafting of burn wounds, thermoregulation, control of infection, early and continuous enteral nutrition, and pharmacologic treatments aimed at mitigating physiologic derangements have markedly decreased morbidity.

AB - Severe burn injury is followed by a profound hypermetabolic response that persists up to 2 years after injury. It is mediated by up to 50-fold elevations in plasma catecholamines, cortisol, and glucagon that lead to whole-body catabolism, elevated resting energy expenditures, and multiorgan dysfunction. Modulation of the response by early excision and grafting of burn wounds, thermoregulation, control of infection, early and continuous enteral nutrition, and pharmacologic treatments aimed at mitigating physiologic derangements have markedly decreased morbidity.

KW - Catecholamines

KW - Hypercatabolism

KW - Hypermetabolism

KW - Insulin resistance

KW - Nutrition

KW - Oxandrolone

KW - Propranolol

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DO - 10.1016/j.cps.2017.02.013

M3 - Review article

C2 - 28576243

AN - SCOPUS:85018656606

SN - 0094-1298

VL - 44

SP - 541

EP - 553

JO - Clinics in Plastic Surgery

JF - Clinics in Plastic Surgery

IS - 3

ER -

Metabolic and Endocrine Considerations After Burn Injury

Abstract

Keywords

ASJC Scopus subject areas

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