Metabolic and Endocrine Considerations After Burn Injury

Felicia N. Williams, David N. Herndon

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Severe burn injury is followed by a profound hypermetabolic response that persists up to 2 years after injury. It is mediated by up to 50-fold elevations in plasma catecholamines, cortisol, and glucagon that lead to whole-body catabolism, elevated resting energy expenditures, and multiorgan dysfunction. Modulation of the response by early excision and grafting of burn wounds, thermoregulation, control of infection, early and continuous enteral nutrition, and pharmacologic treatments aimed at mitigating physiologic derangements have markedly decreased morbidity.

Original languageEnglish (US)
Pages (from-to)541-553
Number of pages13
JournalClinics in Plastic Surgery
Volume44
Issue number3
DOIs
StatePublished - Jul 2017
Externally publishedYes

Keywords

  • Catecholamines
  • Hypercatabolism
  • Hypermetabolism
  • Insulin resistance
  • Nutrition
  • Oxandrolone
  • Propranolol

ASJC Scopus subject areas

  • Surgery

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