Metabolic and hormonal changes of severely burned children receiving long-term oxandrolone treatment

Rene Przkora, Marc G. Jeschke, Robert E. Barrow, Oscar Suman, Walter Meyer, Celeste Finnerty, Arthur P. Sanford, Jong Lee, David L. Chinkes, Ronald P. Mlcak, David Herndon, Basil A. Pruitt, Richard L. Gamelli

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Objective: When given to children for 1 year after a severe burn, oxandrolone significantly improves lean body mass, bone mineral content, and muscle strength. The beneficial effects of oxandrolone on height and weight were observed 1 year after treatment was discontinued. To study the efficacy of oxandrolone in severely burned children for 12 months after burn and 12 months after the drug was discontinued. Summary Background Data: Oxandrolone attenuates body catabolism during the acute phase after burn. It is unclear whether oxandrolone would have any beneficial effects during long-term treatment or if there were any effects after the drug was stopped. Methods: Sixty-one children with 40% total body surface area burns were enrolled in this study. Patients were randomized into those to receive oxandrolone (n = 30) or placebo (n = 31) for the first 12 months. Treatment was discontinued after 12 months, and the patients were studied without the drug for the following 12 months. At discharge and 6, 12, 18, and 24 months after burn, height, weight, body composition, resting energy expenditure, muscle strength, and serum human growth hormone, insulin-like growth factor-I (IGF-1), IGF binding protein-3, insulin, cortisol, parathyroid hormone, tri-iodothyronine uptake (T3 uptake), and free thyroxine index (FTI) were measured. Statistical analysis used Tukey multiple comparison test. Significance was accepted at P < 0.05. Results: Oxandrolone improved lean body mass, bone mineral content and muscle strength compared with controls during treatment, P < 0.05. Serum IGF-1, T3 uptake, and FTI were significantly higher during drug treatment compared with controls, P < 0.05. Significant increases in height and weight with oxandrolone were observed after the end of treatment. Conclusions: Oxandrolone improved body composition and strength in severely burned children during the 12 months of treatment. Its effect on height and weight continued after treatment was discontinued.

Original languageEnglish (US)
Pages (from-to)384-391
Number of pages8
JournalAnnals of Surgery
Volume242
Issue number3
DOIs
StatePublished - Sep 2005

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Oxandrolone
Muscle Strength
Insulin-Like Growth Factor I
Weights and Measures
Therapeutics
Body Composition
Thyroxine
Pharmaceutical Preparations
Bone Density
Insulin-Like Growth Factor Binding Protein 3
Human Growth Hormone
Body Surface Area
Parathyroid Hormone
Serum
Burns
Energy Metabolism
Hydrocortisone
Placebos

ASJC Scopus subject areas

  • Surgery

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Metabolic and hormonal changes of severely burned children receiving long-term oxandrolone treatment. / Przkora, Rene; Jeschke, Marc G.; Barrow, Robert E.; Suman, Oscar; Meyer, Walter; Finnerty, Celeste; Sanford, Arthur P.; Lee, Jong; Chinkes, David L.; Mlcak, Ronald P.; Herndon, David; Pruitt, Basil A.; Gamelli, Richard L.

In: Annals of Surgery, Vol. 242, No. 3, 09.2005, p. 384-391.

Research output: Contribution to journalArticle

Przkora, R, Jeschke, MG, Barrow, RE, Suman, O, Meyer, W, Finnerty, C, Sanford, AP, Lee, J, Chinkes, DL, Mlcak, RP, Herndon, D, Pruitt, BA & Gamelli, RL 2005, 'Metabolic and hormonal changes of severely burned children receiving long-term oxandrolone treatment', Annals of Surgery, vol. 242, no. 3, pp. 384-391. https://doi.org/10.1097/01.sla.0000180398.70103.24
Przkora, Rene ; Jeschke, Marc G. ; Barrow, Robert E. ; Suman, Oscar ; Meyer, Walter ; Finnerty, Celeste ; Sanford, Arthur P. ; Lee, Jong ; Chinkes, David L. ; Mlcak, Ronald P. ; Herndon, David ; Pruitt, Basil A. ; Gamelli, Richard L. / Metabolic and hormonal changes of severely burned children receiving long-term oxandrolone treatment. In: Annals of Surgery. 2005 ; Vol. 242, No. 3. pp. 384-391.
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abstract = "Objective: When given to children for 1 year after a severe burn, oxandrolone significantly improves lean body mass, bone mineral content, and muscle strength. The beneficial effects of oxandrolone on height and weight were observed 1 year after treatment was discontinued. To study the efficacy of oxandrolone in severely burned children for 12 months after burn and 12 months after the drug was discontinued. Summary Background Data: Oxandrolone attenuates body catabolism during the acute phase after burn. It is unclear whether oxandrolone would have any beneficial effects during long-term treatment or if there were any effects after the drug was stopped. Methods: Sixty-one children with 40{\%} total body surface area burns were enrolled in this study. Patients were randomized into those to receive oxandrolone (n = 30) or placebo (n = 31) for the first 12 months. Treatment was discontinued after 12 months, and the patients were studied without the drug for the following 12 months. At discharge and 6, 12, 18, and 24 months after burn, height, weight, body composition, resting energy expenditure, muscle strength, and serum human growth hormone, insulin-like growth factor-I (IGF-1), IGF binding protein-3, insulin, cortisol, parathyroid hormone, tri-iodothyronine uptake (T3 uptake), and free thyroxine index (FTI) were measured. Statistical analysis used Tukey multiple comparison test. Significance was accepted at P < 0.05. Results: Oxandrolone improved lean body mass, bone mineral content and muscle strength compared with controls during treatment, P < 0.05. Serum IGF-1, T3 uptake, and FTI were significantly higher during drug treatment compared with controls, P < 0.05. Significant increases in height and weight with oxandrolone were observed after the end of treatment. Conclusions: Oxandrolone improved body composition and strength in severely burned children during the 12 months of treatment. Its effect on height and weight continued after treatment was discontinued.",
author = "Rene Przkora and Jeschke, {Marc G.} and Barrow, {Robert E.} and Oscar Suman and Walter Meyer and Celeste Finnerty and Sanford, {Arthur P.} and Jong Lee and Chinkes, {David L.} and Mlcak, {Ronald P.} and David Herndon and Pruitt, {Basil A.} and Gamelli, {Richard L.}",
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T1 - Metabolic and hormonal changes of severely burned children receiving long-term oxandrolone treatment

AU - Przkora, Rene

AU - Jeschke, Marc G.

AU - Barrow, Robert E.

AU - Suman, Oscar

AU - Meyer, Walter

AU - Finnerty, Celeste

AU - Sanford, Arthur P.

AU - Lee, Jong

AU - Chinkes, David L.

AU - Mlcak, Ronald P.

AU - Herndon, David

AU - Pruitt, Basil A.

AU - Gamelli, Richard L.

PY - 2005/9

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N2 - Objective: When given to children for 1 year after a severe burn, oxandrolone significantly improves lean body mass, bone mineral content, and muscle strength. The beneficial effects of oxandrolone on height and weight were observed 1 year after treatment was discontinued. To study the efficacy of oxandrolone in severely burned children for 12 months after burn and 12 months after the drug was discontinued. Summary Background Data: Oxandrolone attenuates body catabolism during the acute phase after burn. It is unclear whether oxandrolone would have any beneficial effects during long-term treatment or if there were any effects after the drug was stopped. Methods: Sixty-one children with 40% total body surface area burns were enrolled in this study. Patients were randomized into those to receive oxandrolone (n = 30) or placebo (n = 31) for the first 12 months. Treatment was discontinued after 12 months, and the patients were studied without the drug for the following 12 months. At discharge and 6, 12, 18, and 24 months after burn, height, weight, body composition, resting energy expenditure, muscle strength, and serum human growth hormone, insulin-like growth factor-I (IGF-1), IGF binding protein-3, insulin, cortisol, parathyroid hormone, tri-iodothyronine uptake (T3 uptake), and free thyroxine index (FTI) were measured. Statistical analysis used Tukey multiple comparison test. Significance was accepted at P < 0.05. Results: Oxandrolone improved lean body mass, bone mineral content and muscle strength compared with controls during treatment, P < 0.05. Serum IGF-1, T3 uptake, and FTI were significantly higher during drug treatment compared with controls, P < 0.05. Significant increases in height and weight with oxandrolone were observed after the end of treatment. Conclusions: Oxandrolone improved body composition and strength in severely burned children during the 12 months of treatment. Its effect on height and weight continued after treatment was discontinued.

AB - Objective: When given to children for 1 year after a severe burn, oxandrolone significantly improves lean body mass, bone mineral content, and muscle strength. The beneficial effects of oxandrolone on height and weight were observed 1 year after treatment was discontinued. To study the efficacy of oxandrolone in severely burned children for 12 months after burn and 12 months after the drug was discontinued. Summary Background Data: Oxandrolone attenuates body catabolism during the acute phase after burn. It is unclear whether oxandrolone would have any beneficial effects during long-term treatment or if there were any effects after the drug was stopped. Methods: Sixty-one children with 40% total body surface area burns were enrolled in this study. Patients were randomized into those to receive oxandrolone (n = 30) or placebo (n = 31) for the first 12 months. Treatment was discontinued after 12 months, and the patients were studied without the drug for the following 12 months. At discharge and 6, 12, 18, and 24 months after burn, height, weight, body composition, resting energy expenditure, muscle strength, and serum human growth hormone, insulin-like growth factor-I (IGF-1), IGF binding protein-3, insulin, cortisol, parathyroid hormone, tri-iodothyronine uptake (T3 uptake), and free thyroxine index (FTI) were measured. Statistical analysis used Tukey multiple comparison test. Significance was accepted at P < 0.05. Results: Oxandrolone improved lean body mass, bone mineral content and muscle strength compared with controls during treatment, P < 0.05. Serum IGF-1, T3 uptake, and FTI were significantly higher during drug treatment compared with controls, P < 0.05. Significant increases in height and weight with oxandrolone were observed after the end of treatment. Conclusions: Oxandrolone improved body composition and strength in severely burned children during the 12 months of treatment. Its effect on height and weight continued after treatment was discontinued.

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