Metabolic basis of HIV-lipodystrophy syndrome

Rajagopal V. Sekhar, Farook Jahoor, A. Clinton White, Henry J. Pownall, Fehmida Visnegarwala, Maria C. Rodriguez-Barradas, Morali Sharma, Peter J. Reeds, Ashok Balasubramanyam

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Human immunodeficiency virus (HIV)-lipodystrophy syndrome (HLS) is characterized by hypertriglyceridemia, low high-density lipoprotein-cholesterol, lipoatrophy, and central adiposity. We investigated fasting lipid metabolism in six men with HLS and six non-HIV-infected controls. Compared with controls, HLS patients had lower fat mass (15.9 ± 1.3 vs. 22.3 ± 1.7 kg, P < 0.05) but higher plasma glycerol rate of appearance (Ra), an index of total lipolysis (964.71 ± 103.33 vs. 611.08 ± 63.38 μmol·kg fat-1·h-1, P " 0.05), Ra palmitate, an index of net lipolysis (731.49 ± 72.36 vs. 419.72 ± 33.78 μmol·kg fat-1·h-, P < 0.01), Ra free fatty acids (2,094.74 ± 182.18 vs. 1,470.87 ± 202.80 μmol·kg fat-1·h-1, P < 0.05), and rates of intra-adipocyte (799.40 ± 157.69 vs. 362.36 ± 74.87 μmol·kg fat-1·h-1, P ± 0.01) and intrahepatic fatty acid reesterification (1,352.08 ± 123.90 vs. 955.56 ± 124.09 μmol·kg fat-1·h-1, P " 0.05). Resting energy expenditure was increased in HLS patients (30.51 ± 2.53 vs. 25.34 ± 1.04 kcal·kg lean body mass-1·day-1·, P < 0.05), associated with increased non-plasma-derived fatty acid oxidation (139.04 ± 24.17 vs. 47.87 ± 18.81 μmol·kg lean body mass-1·min-1, P " 0.02). The lipoatrophy observed in HIV lipodystrophy is associated with accelerated lipolysis. Increased hepatic reesterification promotes the hypertriglyceridemia observed in this syndrome.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume283
Issue number2 46-2
StatePublished - 2002
Externally publishedYes

Fingerprint

Lipodystrophy
Viruses
HIV-Associated Lipodystrophy Syndrome
Fats
HIV
Lipolysis
Hypertriglyceridemia
Fatty Acids
Palmitates
Adiposity
Lipid Metabolism
Nonesterified Fatty Acids
Adipocytes
LDL Cholesterol
Glycerol
HDL Cholesterol
Energy Metabolism
Fasting
Plasmas
Oxidation

Keywords

  • High-density lipoprotein-cholesterol
  • Hypertriglyceridemia
  • Lipolysis
  • Very low density lipoprotein

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Biochemistry

Cite this

Sekhar, R. V., Jahoor, F., White, A. C., Pownall, H. J., Visnegarwala, F., Rodriguez-Barradas, M. C., ... Balasubramanyam, A. (2002). Metabolic basis of HIV-lipodystrophy syndrome. American Journal of Physiology - Endocrinology and Metabolism, 283(2 46-2).

Metabolic basis of HIV-lipodystrophy syndrome. / Sekhar, Rajagopal V.; Jahoor, Farook; White, A. Clinton; Pownall, Henry J.; Visnegarwala, Fehmida; Rodriguez-Barradas, Maria C.; Sharma, Morali; Reeds, Peter J.; Balasubramanyam, Ashok.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 283, No. 2 46-2, 2002.

Research output: Contribution to journalArticle

Sekhar, RV, Jahoor, F, White, AC, Pownall, HJ, Visnegarwala, F, Rodriguez-Barradas, MC, Sharma, M, Reeds, PJ & Balasubramanyam, A 2002, 'Metabolic basis of HIV-lipodystrophy syndrome', American Journal of Physiology - Endocrinology and Metabolism, vol. 283, no. 2 46-2.
Sekhar RV, Jahoor F, White AC, Pownall HJ, Visnegarwala F, Rodriguez-Barradas MC et al. Metabolic basis of HIV-lipodystrophy syndrome. American Journal of Physiology - Endocrinology and Metabolism. 2002;283(2 46-2).
Sekhar, Rajagopal V. ; Jahoor, Farook ; White, A. Clinton ; Pownall, Henry J. ; Visnegarwala, Fehmida ; Rodriguez-Barradas, Maria C. ; Sharma, Morali ; Reeds, Peter J. ; Balasubramanyam, Ashok. / Metabolic basis of HIV-lipodystrophy syndrome. In: American Journal of Physiology - Endocrinology and Metabolism. 2002 ; Vol. 283, No. 2 46-2.
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