Metabolic changes following major burn injury

How to improve outcome

William Norbury, M. G. Jeschke, David Herndon

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

The changes in patient metabolism following a major burn may be seen for more than 12 months after the initial injury. The ensuing period of hypermetabolism and catabolism post-burn leads to impaired immune function, decreased wound healing, erosion of lean body mass, and hinders rehabilitative efforts delaying reintegration into normal society. The typical changes in metabolism are the development of a hyperdynamic circulation [1], increased body temperature [2], increased protein catabolism with peripheral protein wasting [3], increased lipolysis leading to fatty infiltration of the liver [4], increased glycolysis and futile substrate cycling 5. These changes are responsible for much of the morbidity and mortality seen with such an injury and as such are important targets for available treatments including: early excision and grafting; aggressive treatment of sepsis, early commencement of high protein, high carbohydrate enteral feeding, elevation of the immediate environmental temperature to 31.5°C (±0.7°C); and early institution of an aerobic resistive exercise program. Several pharmacotherapeutic options are also available to further reduce erosion of lean body mass; these include anabolic agents such as recombinant human growth hormone, insulin, oxandrolone and beta-blockade with propranolol. This chapter will discuss the metabolic changes seen following a major burn and how different treatment options affect outcome.

Original languageEnglish
Title of host publicationIntensive Care Medicine: Annual Update 2006
PublisherSpringer New York
Pages514-524
Number of pages11
ISBN (Print)0387301569, 9780387301563
DOIs
StatePublished - 2007

Fingerprint

Wounds and Injuries
Oxandrolone
Substrate Cycling
Anabolic Agents
Proteins
Human Growth Hormone
Lipolysis
Enteral Nutrition
Glycolysis
Fatty Liver
Body Temperature
Burns
Propranolol
Wound Healing
Growth Hormone
Sepsis
Therapeutics
Carbohydrates
Exercise
Insulin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Norbury, W., Jeschke, M. G., & Herndon, D. (2007). Metabolic changes following major burn injury: How to improve outcome. In Intensive Care Medicine: Annual Update 2006 (pp. 514-524). Springer New York. https://doi.org/10.1007/0-387-35096-9_48

Metabolic changes following major burn injury : How to improve outcome. / Norbury, William; Jeschke, M. G.; Herndon, David.

Intensive Care Medicine: Annual Update 2006. Springer New York, 2007. p. 514-524.

Research output: Chapter in Book/Report/Conference proceedingChapter

Norbury, W, Jeschke, MG & Herndon, D 2007, Metabolic changes following major burn injury: How to improve outcome. in Intensive Care Medicine: Annual Update 2006. Springer New York, pp. 514-524. https://doi.org/10.1007/0-387-35096-9_48
Norbury W, Jeschke MG, Herndon D. Metabolic changes following major burn injury: How to improve outcome. In Intensive Care Medicine: Annual Update 2006. Springer New York. 2007. p. 514-524 https://doi.org/10.1007/0-387-35096-9_48
Norbury, William ; Jeschke, M. G. ; Herndon, David. / Metabolic changes following major burn injury : How to improve outcome. Intensive Care Medicine: Annual Update 2006. Springer New York, 2007. pp. 514-524
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