Abstract
Macrophages (Mφ)are central players in mediating proinflammatory and immunomodulatory functions. Unchecked Mφ activities contribute to pathology across many diseases, including those caused by infectious pathogens and metabolic disorders. A fine balance of Mφ responses is crucial, which may be achieved by enforcing appropriate bioenergetics pathways. Metabolism serves as the provider of energy, substrates, and byproducts that support differential Mφ characteristics. The metabolic properties that control the polarization and response of Mφ remain to be fully uncovered for use in managing infectious diseases. Here, we review the various metabolic states in Mφ and how they influence the cell function.
| Original language | English (US) |
|---|---|
| Article number | 101198 |
| Journal | Redox Biology |
| Volume | 24 |
| DOIs | |
| State | Published - Jun 1 2019 |
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ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
Cite this
Metabolic programming of macrophage functions and pathogens control. / Koo, Sue jie; Garg, Nisha.
In: Redox Biology, Vol. 24, 101198, 01.06.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Metabolic programming of macrophage functions and pathogens control
AU - Koo, Sue jie
AU - Garg, Nisha
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Macrophages (Mφ)are central players in mediating proinflammatory and immunomodulatory functions. Unchecked Mφ activities contribute to pathology across many diseases, including those caused by infectious pathogens and metabolic disorders. A fine balance of Mφ responses is crucial, which may be achieved by enforcing appropriate bioenergetics pathways. Metabolism serves as the provider of energy, substrates, and byproducts that support differential Mφ characteristics. The metabolic properties that control the polarization and response of Mφ remain to be fully uncovered for use in managing infectious diseases. Here, we review the various metabolic states in Mφ and how they influence the cell function.
AB - Macrophages (Mφ)are central players in mediating proinflammatory and immunomodulatory functions. Unchecked Mφ activities contribute to pathology across many diseases, including those caused by infectious pathogens and metabolic disorders. A fine balance of Mφ responses is crucial, which may be achieved by enforcing appropriate bioenergetics pathways. Metabolism serves as the provider of energy, substrates, and byproducts that support differential Mφ characteristics. The metabolic properties that control the polarization and response of Mφ remain to be fully uncovered for use in managing infectious diseases. Here, we review the various metabolic states in Mφ and how they influence the cell function.
UR - http://www.scopus.com/inward/record.url?scp=85064728756&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064728756&partnerID=8YFLogxK
U2 - 10.1016/j.redox.2019.101198
DO - 10.1016/j.redox.2019.101198
M3 - Review article
VL - 24
JO - Redox Biology
JF - Redox Biology
SN - 2213-2317
M1 - 101198
ER -