Metabolic rate alterations in early excision and grafting versus conservative treatment

Thomas C. Rutan, David N. Herndon, Tim Van Osten, Sally Abston

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


This study was done to determine whether early massive excision and grafting would decrease the hypermetabolic response that characterizes burn injury. Thirteen consecutively admitted adult males with burns over more than 45% of the total body surface area (TBSA) were randomly assigned to one of two treatment groups. One group was treated by excising the burn within 72 hours of injury and grafting with autograft overlaid with cadaveric allograft or cadaveric allograft alone depending on available donor sites and size of recipient areas. The second group was treated conservatively with daily hydrotherapy and twice daily applications of topical antimicrobial agents until granulating beds could receive autografts. Resting energy expenditure (REE) was calculated from measurement of v02 and vC02 at the patient’s bedside. The responses of the two groups were comparable: the REE was approximately 20—30% above the predicted basal metabolic rate (BMR). Excisional therapy did not markedly decrease the hypermetabolic response to burn injury.

Original languageEnglish (US)
Pages (from-to)140-142
Number of pages3
JournalJournal of Trauma - Injury, Infection and Critical Care
Issue number2
StatePublished - Feb 1986

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine


Dive into the research topics of 'Metabolic rate alterations in early excision and grafting versus conservative treatment'. Together they form a unique fingerprint.

Cite this