Abstract
The metabolism of isoflurane and the investigational volatile anaesthetic desflurane to fluoride ion was examined in 25 surgical patients. The patients were randomly assigned to four groups, to receive isoflurane or desflurane at either 0.65 MAC or 1.25 MAC. Anaesthesia was induced in all patients with thiopentone and midazolam and included nitrous oxide 60% in addition to the volatile agent. Blood was drawn before induction and at the end of the operation for determination of serum fluoride ion concentration. Plasma fluoride ion concentrations increased (+1.36 ± 0.93 μM, P < 0.01) in patients receiving isoflurane but were unchanged (- 0.13 ± 0.50 μM) in patients receiving desflurane. Metabolic release of fluoride ion is less with desflurane than with isoflurane during administration of the anaesthetics to surgical patients, and is unlikely to be of clinical significance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 965-968 |
| Number of pages | 4 |
| Journal | Canadian Journal of Anaesthesia |
| Volume | 38 |
| Issue number | 8 |
| DOIs | |
| State | Published - Nov 1991 |
| Externally published | Yes |
Keywords
- anaesthetics, volatile: desflurane, isoflurane, metabolism
- ions: fluoride
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine