Metapneumovirus and acute wheezing in children

Tuomas Jartti, Bernadette Van Den Hoogen, Roberto P. Garofalo, Albert D.M.E. Osterhaus, Olli Ruuskanen

Research output: Contribution to journalArticlepeer-review

239 Scopus citations

Abstract

A new respiratory virus, human metapneumovirus, was recently identified. We detected this virus by PCR in ten (8%) of 132 consecutive children admitted to Turku Hospital, Finland, for acute expiratory wheezing (median age 7 months, range 4-25). The mean duration of hospital stay was 2.5 days (SD 1.6) and mean duration of respiratory symptoms was 19 days (8). The white blood cell count, C-reactive protein, and regulated upon activation, normal T-cell-expressed and T-cell-secreted (RANTES) concentrations in nasal secretion remained low, whereas interleukin 8 concentrations in nasal secretion were high. Human metapneumovirus is a clinically important causative agent of acute wheezing in young children.

Original languageEnglish (US)
Pages (from-to)1393-1394
Number of pages2
JournalLancet
Volume360
Issue number9343
DOIs
StatePublished - Nov 2 2002

ASJC Scopus subject areas

  • Medicine(all)

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