Metastatic intracranial chordoma in a child with massive pulmonary tumor emboli

Manon Auger, Beverly Raney, David Callender, Patricia Eifel, Nelson G. Ordóntilde;ez

    Research output: Contribution to journalArticle

    17 Scopus citations


    A 27-month-old boy of Hispanic background developed multiple cranial nerve palsies, difficulty swallowing, bloody nasal discharge, and irritability. Radiographic evaluations showed extensive destruction of the clivus by a large tumor that invaded the sphenoid bone, left cavernous sinus, ethmoid sinus, nasal cavity, and left orbit. Multiple pulmonary nodules were also noted. The bone marrow and spinal fluid showed no evident tumor cells. Transnasal biopsy revealed a chordoma. Treatment was initiated with a combination of ifosfamide, mesna, and etoposide along with radiation therapy to the cranial tumor. Shifting pulmonary densities were noted on serial films. Despite some clinical improvement, the child developed rapidly progressive hypoxemia 3 weeks after admission and died. Autopsy showed persistent viable tumor in the primary site and massive pulmonary arteriolar tumor emboli, infarcts, and widespread lung parenchymal metastases. No other sites of tumor involvement were discovered. This is the second child reported with intracranial chordoma, pulmonary metastases at diagnosis, and early death attributed to pulmonary tumor emboli..

    Original languageEnglish (US)
    Pages (from-to)763-770
    Number of pages8
    JournalFetal and Pediatric Pathology
    Issue number5
    StatePublished - Jan 1 1994


    • Metastatic chordoma
    • Pulmonary tumor emboli

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Pathology and Forensic Medicine

    Fingerprint Dive into the research topics of 'Metastatic intracranial chordoma in a child with massive pulmonary tumor emboli'. Together they form a unique fingerprint.

  • Cite this

    Auger, M., Raney, B., Callender, D., Eifel, P., & Ordóntilde;ez, N. G. (1994). Metastatic intracranial chordoma in a child with massive pulmonary tumor emboli. Fetal and Pediatric Pathology, 14(5), 763-770.