Methods to Study West Nile Virus Infection and the Virus-Induced Inflammation in the Brain in a Murine Model

Huanle Luo, Tian Wang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

West Nile virus (WNV), a mosquito-borne neurotropic flavivirus, has become the leading cause of vector-borne viral encephalitis in the United States for the past decades. The murine model of WNV infection is an effective in vivo experimental model to investigate WNV neuropathogenesis in humans. Here, we describe several laboratory protocols to study WNV infection and the virus-induced inflammation in the brain in both in vitro and in vivo murine models.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages41-49
Number of pages9
Volume2585
DOIs
StatePublished - 2023

Publication series

NameMethods in Molecular Biology
Volume2585
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Inflammation
  • Neuropathogenesis
  • West Nile virus

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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