Methylprednisolone reduces excitatory amino acid release following experimental spinal cord injury

Danxia Liu, David J. McAdoo

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Administration of methylprednisolone within several hours after injury to the spinal cord has been shown to reduce subsequent impairment in humans and experimental animals. Secondary damage following initial trauma is probably caused in part by the toxicity of released excitatory amino acids. We demonstrate here that methylprednisolone reduces the release of excitatory amino acids following experimental spinal cord injury in rats.

Original languageEnglish (US)
Pages (from-to)293-297
Number of pages5
JournalBrain Research
Volume609
Issue number1-2
DOIs
StatePublished - Apr 23 1993

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Keywords

  • Excitatory amino acid
  • Methylprednisolone
  • Microdialysis
  • Spinal cord injury

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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