MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

Rolf König, Li Yun Huang, Ronald N. Germain

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Abstract

INTERACTIONS between major histocompatibility complex (MHC) molecules and the CD4 or CDS coreceptors have a major role in intrathymic T-cell selection1. On mature T cells, each of these two glycoproteins is associated with a class-specific bias in MHC molecule recognition by the T-cell receptor. CD4+ T cells respond to antigen in association with MHC class II molecules and CD8+ T cells respond to antigen in association with MHC class I molecules. Physical interaction between the CD4/MHC class II molecules and CD8/MHC class I molecules has been demonstrated by cell adhesion assay2-5, and a binding site for CD8 on class I has been identified6,7. Here we demonstrate that a region of the MHC class II β-chain β2 domain, structurally analogous to the CD8-binding loop in the MHC class I α3 domain, is critical for function with both mouse and human CD4.

Original languageEnglish (US)
Pages (from-to)796-798
Number of pages3
JournalNature
Volume356
Issue number6372
StatePublished - Apr 30 1992

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König, R., Huang, L. Y., & Germain, R. N. (1992). MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8. Nature, 356(6372), 796-798.