MHC Class III RNA Binding Proteins and Immunity

Geraldine Schott; Mariano A. Garcia-Blanco

doi:10.1080/15476286.2020.1860388

MHC Class III RNA Binding Proteins and Immunity

Geraldine Schott, Mariano A. Garcia-Blanco

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Here we review data suggestive of a role for RNA-binding proteins in vertebrate immunity. We focus on the products of genes found in the class III region of the Major Histocompatibility Complex. Six of these genes, DDX39B (aka BAT1), DXO, LSM2, NELFE, PRRC2A (aka BAT2), and SKIV2L, encode RNA-binding proteins with clear roles in post-transcriptional gene regulation and RNA surveillance. These genes are likely to have important functions in immunity and are associated with autoimmune diseases.

Original language	English (US)
Pages (from-to)	640-646
Number of pages	7
Journal	RNA Biology
Volume	18
Issue number	5
DOIs	https://doi.org/10.1080/15476286.2020.1860388
State	Published - May 4 2021

Keywords

RNA-binding proteins

ASJC Scopus subject areas

Molecular Biology
Cell Biology

Access to Document

10.1080/15476286.2020.1860388

Cite this

@article{059b9be7340e4db1bde85291e53aed33,

title = "MHC Class III RNA Binding Proteins and Immunity",

abstract = "Here we review data suggestive of a role for RNA-binding proteins in vertebrate immunity. We focus on the products of genes found in the class III region of the Major Histocompatibility Complex. Six of these genes, DDX39B (aka BAT1), DXO, LSM2, NELFE, PRRC2A (aka BAT2), and SKIV2L, encode RNA-binding proteins with clear roles in post-transcriptional gene regulation and RNA surveillance. These genes are likely to have important functions in immunity and are associated with autoimmune diseases.",

keywords = "RNA-binding proteins",

author = "Geraldine Schott and Garcia-Blanco, {Mariano A.}",

note = "Publisher Copyright: {\textcopyright} 2020 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2021",

month = may,

day = "4",

doi = "10.1080/15476286.2020.1860388",

language = "English (US)",

volume = "18",

pages = "640--646",

journal = "RNA Biology",

issn = "1547-6286",

publisher = "Taylor and Francis Ltd.",

number = "5",

}

TY - JOUR

T1 - MHC Class III RNA Binding Proteins and Immunity

AU - Schott, Geraldine

AU - Garcia-Blanco, Mariano A.

PY - 2021/5/4

Y1 - 2021/5/4

N2 - Here we review data suggestive of a role for RNA-binding proteins in vertebrate immunity. We focus on the products of genes found in the class III region of the Major Histocompatibility Complex. Six of these genes, DDX39B (aka BAT1), DXO, LSM2, NELFE, PRRC2A (aka BAT2), and SKIV2L, encode RNA-binding proteins with clear roles in post-transcriptional gene regulation and RNA surveillance. These genes are likely to have important functions in immunity and are associated with autoimmune diseases.

AB - Here we review data suggestive of a role for RNA-binding proteins in vertebrate immunity. We focus on the products of genes found in the class III region of the Major Histocompatibility Complex. Six of these genes, DDX39B (aka BAT1), DXO, LSM2, NELFE, PRRC2A (aka BAT2), and SKIV2L, encode RNA-binding proteins with clear roles in post-transcriptional gene regulation and RNA surveillance. These genes are likely to have important functions in immunity and are associated with autoimmune diseases.

KW - RNA-binding proteins

UR - http://www.scopus.com/inward/record.url?scp=85097805939&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85097805939&partnerID=8YFLogxK

U2 - 10.1080/15476286.2020.1860388

DO - 10.1080/15476286.2020.1860388

M3 - Review article

C2 - 33280511

AN - SCOPUS:85097805939

SN - 1547-6286

VL - 18

SP - 640

EP - 646

JO - RNA Biology

JF - RNA Biology

IS - 5

ER -

MHC Class III RNA Binding Proteins and Immunity

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this