TY - JOUR
T1 - MHC Class III RNA Binding Proteins and Immunity
AU - Schott, Geraldine
AU - Garcia-Blanco, Mariano A.
N1 - Funding Information:
We thank many colleagues at UTMB for discussions about the ideas presented here, in particular Eric J. Wagner. We acknowledge support from NIH R01 CA204806, Mildred Hajek Vacek and John Roman Vacek Distinguished Chair, and UTMB startup package (MGB).
Funding Information:
This work was supported by the National Cancer Institute [R01 CA204806]. We thank many colleagues at UTMB for discussions about the ideas presented here, in particular Eric J. Wagner. We acknowledge support from NIH R01 CA204806, Mildred Hajek Vacek and John Roman Vacek Distinguished Chair, and UTMB startup package (MGB).
Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Here we review data suggestive of a role for RNA-binding proteins in vertebrate immunity. We focus on the products of genes found in the class III region of the Major Histocompatibility Complex. Six of these genes, DDX39B (aka BAT1), DXO, LSM2, NELFE, PRRC2A (aka BAT2), and SKIV2L, encode RNA-binding proteins with clear roles in post-transcriptional gene regulation and RNA surveillance. These genes are likely to have important functions in immunity and are associated with autoimmune diseases.
AB - Here we review data suggestive of a role for RNA-binding proteins in vertebrate immunity. We focus on the products of genes found in the class III region of the Major Histocompatibility Complex. Six of these genes, DDX39B (aka BAT1), DXO, LSM2, NELFE, PRRC2A (aka BAT2), and SKIV2L, encode RNA-binding proteins with clear roles in post-transcriptional gene regulation and RNA surveillance. These genes are likely to have important functions in immunity and are associated with autoimmune diseases.
KW - RNA-binding proteins
UR - http://www.scopus.com/inward/record.url?scp=85097805939&partnerID=8YFLogxK
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U2 - 10.1080/15476286.2020.1860388
DO - 10.1080/15476286.2020.1860388
M3 - Review article
C2 - 33280511
AN - SCOPUS:85097805939
VL - 18
SP - 640
EP - 646
JO - RNA Biology
JF - RNA Biology
SN - 1547-6286
IS - 5
ER -