Mice lacking alpha/beta and gamma interferon receptors are susceptible to Junin virus infection

Olga A. Kolokoltsova; Nadezda E. Yun; Allison L. Poussard; Jennifer K. Smith; Jeanon N. Smith; Milagros Salazar; Aida Walker; Chien Te K. Tseng; Judith F. Aronson; Slobodan Paessler

doi:10.1128/JVI.01389-10

Mice lacking alpha/beta and gamma interferon receptors are susceptible to Junin virus infection

Olga A. Kolokoltsova, Nadezda E. Yun, Allison L. Poussard, Jennifer K. Smith, Jeanon N. Smith, Milagros Salazar, Aida Walker, Chien Te K. Tseng, Judith F. Aronson, Slobodan Paessler

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46 Scopus citations

Abstract

Junin virus (JUNV) causes a highly lethal human disease, Argentine hemorrhagic fever. Previous work has demonstrated the requirement for human transferrin receptor 1 for virus entry, and the absence of the receptor was proposed to be a major cause for the resistance of laboratory mice to JUNV infection. In this study, we present for the first time in vivo evidence that the disruption of interferon signaling is sufficient to generate a disease-susceptible mouse model for JUNV infection. After peripheral inoculation with virulent JUNV, adult mice lacking alpha/beta and gamma interferon receptors developed disseminated infection and severe disease.

Original language	English (US)
Pages (from-to)	13063-13067
Number of pages	5
Journal	Journal of virology
Volume	84
Issue number	24
DOIs	https://doi.org/10.1128/JVI.01389-10
State	Published - Dec 2010

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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title = "Mice lacking alpha/beta and gamma interferon receptors are susceptible to Junin virus infection",

abstract = "Junin virus (JUNV) causes a highly lethal human disease, Argentine hemorrhagic fever. Previous work has demonstrated the requirement for human transferrin receptor 1 for virus entry, and the absence of the receptor was proposed to be a major cause for the resistance of laboratory mice to JUNV infection. In this study, we present for the first time in vivo evidence that the disruption of interferon signaling is sufficient to generate a disease-susceptible mouse model for JUNV infection. After peripheral inoculation with virulent JUNV, adult mice lacking alpha/beta and gamma interferon receptors developed disseminated infection and severe disease.",

author = "Kolokoltsova, {Olga A.} and Yun, {Nadezda E.} and Poussard, {Allison L.} and Smith, {Jennifer K.} and Smith, {Jeanon N.} and Milagros Salazar and Aida Walker and Tseng, {Chien Te K.} and Aronson, {Judith F.} and Slobodan Paessler",

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doi = "10.1128/JVI.01389-10",

language = "English (US)",

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TY - JOUR

T1 - Mice lacking alpha/beta and gamma interferon receptors are susceptible to Junin virus infection

AU - Kolokoltsova, Olga A.

AU - Yun, Nadezda E.

AU - Poussard, Allison L.

AU - Smith, Jennifer K.

AU - Smith, Jeanon N.

AU - Salazar, Milagros

AU - Walker, Aida

AU - Tseng, Chien Te K.

AU - Aronson, Judith F.

AU - Paessler, Slobodan

PY - 2010/12

Y1 - 2010/12

N2 - Junin virus (JUNV) causes a highly lethal human disease, Argentine hemorrhagic fever. Previous work has demonstrated the requirement for human transferrin receptor 1 for virus entry, and the absence of the receptor was proposed to be a major cause for the resistance of laboratory mice to JUNV infection. In this study, we present for the first time in vivo evidence that the disruption of interferon signaling is sufficient to generate a disease-susceptible mouse model for JUNV infection. After peripheral inoculation with virulent JUNV, adult mice lacking alpha/beta and gamma interferon receptors developed disseminated infection and severe disease.

AB - Junin virus (JUNV) causes a highly lethal human disease, Argentine hemorrhagic fever. Previous work has demonstrated the requirement for human transferrin receptor 1 for virus entry, and the absence of the receptor was proposed to be a major cause for the resistance of laboratory mice to JUNV infection. In this study, we present for the first time in vivo evidence that the disruption of interferon signaling is sufficient to generate a disease-susceptible mouse model for JUNV infection. After peripheral inoculation with virulent JUNV, adult mice lacking alpha/beta and gamma interferon receptors developed disseminated infection and severe disease.

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Mice lacking alpha/beta and gamma interferon receptors are susceptible to Junin virus infection

Abstract

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