Mice lacking alpha/beta and gamma interferon receptors are susceptible to Junin virus infection

Olga A. Kolokoltsova, Nadezda E. Yun, Allison L. Poussard, Jennifer K. Smith, Jeanon N. Smith, Milagros Salazar, Aida Walker, Chien-Te Tseng, Judith Aronson, Slobodan Paessler

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Junin virus (JUNV) causes a highly lethal human disease, Argentine hemorrhagic fever. Previous work has demonstrated the requirement for human transferrin receptor 1 for virus entry, and the absence of the receptor was proposed to be a major cause for the resistance of laboratory mice to JUNV infection. In this study, we present for the first time in vivo evidence that the disruption of interferon signaling is sufficient to generate a disease-susceptible mouse model for JUNV infection. After peripheral inoculation with virulent JUNV, adult mice lacking alpha/beta and gamma interferon receptors developed disseminated infection and severe disease.

Original languageEnglish
Pages (from-to)13063-13067
Number of pages5
JournalJournal of Virology
Volume84
Issue number24
DOIs
StatePublished - Dec 2010

Fingerprint

Junin virus
Interferon Receptors
Interferon-beta
Virus Diseases
interferon-gamma
Interferon-alpha
Interferon-gamma
receptors
mice
infection
Virus Internalization
biological resistance
transferrin
interferons
human diseases
Interferons
Fever
animal models
viruses
Infection

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Kolokoltsova, O. A., Yun, N. E., Poussard, A. L., Smith, J. K., Smith, J. N., Salazar, M., ... Paessler, S. (2010). Mice lacking alpha/beta and gamma interferon receptors are susceptible to Junin virus infection. Journal of Virology, 84(24), 13063-13067. https://doi.org/10.1128/JVI.01389-10

Mice lacking alpha/beta and gamma interferon receptors are susceptible to Junin virus infection. / Kolokoltsova, Olga A.; Yun, Nadezda E.; Poussard, Allison L.; Smith, Jennifer K.; Smith, Jeanon N.; Salazar, Milagros; Walker, Aida; Tseng, Chien-Te; Aronson, Judith; Paessler, Slobodan.

In: Journal of Virology, Vol. 84, No. 24, 12.2010, p. 13063-13067.

Research output: Contribution to journalArticle

Kolokoltsova, OA, Yun, NE, Poussard, AL, Smith, JK, Smith, JN, Salazar, M, Walker, A, Tseng, C-T, Aronson, J & Paessler, S 2010, 'Mice lacking alpha/beta and gamma interferon receptors are susceptible to Junin virus infection', Journal of Virology, vol. 84, no. 24, pp. 13063-13067. https://doi.org/10.1128/JVI.01389-10
Kolokoltsova OA, Yun NE, Poussard AL, Smith JK, Smith JN, Salazar M et al. Mice lacking alpha/beta and gamma interferon receptors are susceptible to Junin virus infection. Journal of Virology. 2010 Dec;84(24):13063-13067. https://doi.org/10.1128/JVI.01389-10
Kolokoltsova, Olga A. ; Yun, Nadezda E. ; Poussard, Allison L. ; Smith, Jennifer K. ; Smith, Jeanon N. ; Salazar, Milagros ; Walker, Aida ; Tseng, Chien-Te ; Aronson, Judith ; Paessler, Slobodan. / Mice lacking alpha/beta and gamma interferon receptors are susceptible to Junin virus infection. In: Journal of Virology. 2010 ; Vol. 84, No. 24. pp. 13063-13067.
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