Mice lacking alpha/beta and gamma interferon receptors are susceptible to Junin virus infection

Olga A. Kolokoltsova, Nadezda E. Yun, Allison L. Poussard, Jennifer K. Smith, Jeanon N. Smith, Milagros Salazar, Aida Walker, Chien Te K. Tseng, Judith F. Aronson, Slobodan Paessler

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Junin virus (JUNV) causes a highly lethal human disease, Argentine hemorrhagic fever. Previous work has demonstrated the requirement for human transferrin receptor 1 for virus entry, and the absence of the receptor was proposed to be a major cause for the resistance of laboratory mice to JUNV infection. In this study, we present for the first time in vivo evidence that the disruption of interferon signaling is sufficient to generate a disease-susceptible mouse model for JUNV infection. After peripheral inoculation with virulent JUNV, adult mice lacking alpha/beta and gamma interferon receptors developed disseminated infection and severe disease.

Original languageEnglish (US)
Pages (from-to)13063-13067
Number of pages5
JournalJournal of virology
Volume84
Issue number24
DOIs
StatePublished - Dec 1 2010

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Kolokoltsova, O. A., Yun, N. E., Poussard, A. L., Smith, J. K., Smith, J. N., Salazar, M., Walker, A., Tseng, C. T. K., Aronson, J. F., & Paessler, S. (2010). Mice lacking alpha/beta and gamma interferon receptors are susceptible to Junin virus infection. Journal of virology, 84(24), 13063-13067. https://doi.org/10.1128/JVI.01389-10