Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus

Nadezhda E. Yun, Alexey V. Seregin, David H. Walker, Vsevolod L. Popov, Aida G. Walker, Jeanon N. Smith, Milagros Miller, Juan C. de la Torre, Jennifer K. Smith, Viktoriya Borisevich, Joseph N. Fair, Nadia Wauquier, Donald S. Grant, Bayon Bockarie, Dennis Bente, Slobodan Paessler

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29 Scopus citations

Abstract

Lassa fever (LF) is a potentially lethal human disease that is caused by the arenavirus Lassa virus (LASV). Annually, around 300,000 infections with up to 10,000 deaths occur in regions of Lassa fever endemicity in West Africa. Here we demonstrate that mice lacking a functional STAT1 pathway are highly susceptible to infection with LASV and develop lethal disease with pathology similar to that reported in humans.

Original languageEnglish (US)
Pages (from-to)10908-10911
Number of pages4
JournalJournal of virology
Volume87
Issue number19
DOIs
StatePublished - Oct 28 2013

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Yun, N. E., Seregin, A. V., Walker, D. H., Popov, V. L., Walker, A. G., Smith, J. N., Miller, M., de la Torre, J. C., Smith, J. K., Borisevich, V., Fair, J. N., Wauquier, N., Grant, D. S., Bockarie, B., Bente, D., & Paessler, S. (2013). Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus. Journal of virology, 87(19), 10908-10911. https://doi.org/10.1128/JVI.01433-13