Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus

Nadezhda E. Yun, Alexey V. Seregin, David Walker, Vsevolod Popov, Aida G. Walker, Jeanon N. Smith, Milagros Miller, Juan C. de la Torre, Jennifer K. Smith, Viktoriya Borisevich, Joseph N. Fair, Nadia Wauquier, Donald S. Grant, Bayon Bockarie, Dennis Bente, Slobodan Paessler

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Lassa fever (LF) is a potentially lethal human disease that is caused by the arenavirus Lassa virus (LASV). Annually, around 300,000 infections with up to 10,000 deaths occur in regions of Lassa fever endemicity in West Africa. Here we demonstrate that mice lacking a functional STAT1 pathway are highly susceptible to infection with LASV and develop lethal disease with pathology similar to that reported in humans.

Original languageEnglish (US)
Pages (from-to)10908-10911
Number of pages4
JournalJournal of Virology
Volume87
Issue number19
DOIs
StatePublished - 2013

Fingerprint

Lassa virus
Lassa Fever
fever
Arenavirus
Western Africa
biological resistance
mice
Infection
human diseases
infection
indigenous species
Pathology
death

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus. / Yun, Nadezhda E.; Seregin, Alexey V.; Walker, David; Popov, Vsevolod; Walker, Aida G.; Smith, Jeanon N.; Miller, Milagros; de la Torre, Juan C.; Smith, Jennifer K.; Borisevich, Viktoriya; Fair, Joseph N.; Wauquier, Nadia; Grant, Donald S.; Bockarie, Bayon; Bente, Dennis; Paessler, Slobodan.

In: Journal of Virology, Vol. 87, No. 19, 2013, p. 10908-10911.

Research output: Contribution to journalArticle

Yun, NE, Seregin, AV, Walker, D, Popov, V, Walker, AG, Smith, JN, Miller, M, de la Torre, JC, Smith, JK, Borisevich, V, Fair, JN, Wauquier, N, Grant, DS, Bockarie, B, Bente, D & Paessler, S 2013, 'Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus', Journal of Virology, vol. 87, no. 19, pp. 10908-10911. https://doi.org/10.1128/JVI.01433-13
Yun, Nadezhda E. ; Seregin, Alexey V. ; Walker, David ; Popov, Vsevolod ; Walker, Aida G. ; Smith, Jeanon N. ; Miller, Milagros ; de la Torre, Juan C. ; Smith, Jennifer K. ; Borisevich, Viktoriya ; Fair, Joseph N. ; Wauquier, Nadia ; Grant, Donald S. ; Bockarie, Bayon ; Bente, Dennis ; Paessler, Slobodan. / Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus. In: Journal of Virology. 2013 ; Vol. 87, No. 19. pp. 10908-10911.
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AU - Yun, Nadezhda E.

AU - Seregin, Alexey V.

AU - Walker, David

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AU - Walker, Aida G.

AU - Smith, Jeanon N.

AU - Miller, Milagros

AU - de la Torre, Juan C.

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AU - Borisevich, Viktoriya

AU - Fair, Joseph N.

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AU - Grant, Donald S.

AU - Bockarie, Bayon

AU - Bente, Dennis

AU - Paessler, Slobodan

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