Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus

Nadezhda E. Yun; Alexey V. Seregin; David H. Walker; Vsevolod L. Popov; Aida G. Walker; Jeanon N. Smith; Milagros Miller; Juan C. de la Torre; Jennifer K. Smith; Viktoriya Borisevich; Joseph N. Fair; Nadia Wauquier; Donald S. Grant; Bayon Bockarie; Dennis Bente; Slobodan Paessler

doi:10.1128/JVI.01433-13

Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus

Nadezhda E. Yun, Alexey V. Seregin, David H. Walker, Vsevolod L. Popov, Aida G. Walker, Jeanon N. Smith, Milagros Miller, Juan C. de la Torre, Jennifer K. Smith, Viktoriya Borisevich, Joseph N. Fair, Nadia Wauquier, Donald S. Grant, Bayon Bockarie, Dennis Bente, Slobodan Paessler

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Lassa fever (LF) is a potentially lethal human disease that is caused by the arenavirus Lassa virus (LASV). Annually, around 300,000 infections with up to 10,000 deaths occur in regions of Lassa fever endemicity in West Africa. Here we demonstrate that mice lacking a functional STAT1 pathway are highly susceptible to infection with LASV and develop lethal disease with pathology similar to that reported in humans.

Original language	English (US)
Pages (from-to)	10908-10911
Number of pages	4
Journal	Journal of virology
Volume	87
Issue number	19
DOIs	https://doi.org/10.1128/JVI.01433-13
State	Published - 2013

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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Yun, N. E., Seregin, A. V., Walker, D. H., Popov, V. L., Walker, A. G., Smith, J. N., Miller, M., de la Torre, J. C., Smith, J. K., Borisevich, V., Fair, J. N., Wauquier, N., Grant, D. S., Bockarie, B., Bente, D., & Paessler, S. (2013). Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus. Journal of virology, 87(19), 10908-10911. https://doi.org/10.1128/JVI.01433-13

Yun, NE, Seregin, AV, Walker, DH , Popov, VL, Walker, AG, Smith, JN, Miller, M, de la Torre, JC, Smith, JK, Borisevich, V, Fair, JN, Wauquier, N, Grant, DS, Bockarie, B, Bente, D & Paessler, S 2013, 'Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus', Journal of virology, vol. 87, no. 19, pp. 10908-10911. https://doi.org/10.1128/JVI.01433-13

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title = "Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus",

abstract = "Lassa fever (LF) is a potentially lethal human disease that is caused by the arenavirus Lassa virus (LASV). Annually, around 300,000 infections with up to 10,000 deaths occur in regions of Lassa fever endemicity in West Africa. Here we demonstrate that mice lacking a functional STAT1 pathway are highly susceptible to infection with LASV and develop lethal disease with pathology similar to that reported in humans.",

author = "Yun, {Nadezhda E.} and Seregin, {Alexey V.} and Walker, {David H.} and Popov, {Vsevolod L.} and Walker, {Aida G.} and Smith, {Jeanon N.} and Milagros Miller and {de la Torre}, {Juan C.} and Smith, {Jennifer K.} and Viktoriya Borisevich and Fair, {Joseph N.} and Nadia Wauquier and Grant, {Donald S.} and Bayon Bockarie and Dennis Bente and Slobodan Paessler",

year = "2013",

doi = "10.1128/JVI.01433-13",

language = "English (US)",

volume = "87",

pages = "10908--10911",

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T1 - Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus

AU - Yun, Nadezhda E.

AU - Seregin, Alexey V.

AU - Walker, David H.

AU - Popov, Vsevolod L.

AU - Walker, Aida G.

AU - Smith, Jeanon N.

AU - Miller, Milagros

AU - de la Torre, Juan C.

AU - Smith, Jennifer K.

AU - Borisevich, Viktoriya

AU - Fair, Joseph N.

AU - Wauquier, Nadia

AU - Grant, Donald S.

AU - Bockarie, Bayon

AU - Bente, Dennis

AU - Paessler, Slobodan

PY - 2013

Y1 - 2013

N2 - Lassa fever (LF) is a potentially lethal human disease that is caused by the arenavirus Lassa virus (LASV). Annually, around 300,000 infections with up to 10,000 deaths occur in regions of Lassa fever endemicity in West Africa. Here we demonstrate that mice lacking a functional STAT1 pathway are highly susceptible to infection with LASV and develop lethal disease with pathology similar to that reported in humans.

AB - Lassa fever (LF) is a potentially lethal human disease that is caused by the arenavirus Lassa virus (LASV). Annually, around 300,000 infections with up to 10,000 deaths occur in regions of Lassa fever endemicity in West Africa. Here we demonstrate that mice lacking a functional STAT1 pathway are highly susceptible to infection with LASV and develop lethal disease with pathology similar to that reported in humans.

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SN - 0022-538X

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EP - 10911

JO - Journal of virology

JF - Journal of virology

IS - 19

ER -

Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus

Abstract

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