Microbial control of arthropod-borne disease

Miguel A. Saldaña, Shivanand Hegde, Grant L. Hughes

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Arthropods harbor a diverse array of microbes that profoundly influence many aspects of host biology, including vector competence. Additionally, symbionts can be engineered to produce molecules that inhibit pathogens. Due to their intimate association with the host, microbes have developed strategies that facilitate their transmission, either horizontally or vertically, to conspecifics. These attributes make microbes attractive agents for applied strategies to control arthropod-borne disease. Here we discuss the recent advances in microbial control approaches to reduce the burden of pathogens such as Zika, Dengue and Chikungunya viruses, and Trypanosome and Plasmodium parasites. We also highlight where further investigation is warranted.

Original languageEnglish (US)
Pages (from-to)81-93
Number of pages13
JournalMemorias do Instituto Oswaldo Cruz
Volume112
Issue number2
DOIs
StatePublished - Feb 2017

Keywords

  • Arbovirus
  • Malaria
  • Microbiome
  • Mosquito
  • Paratransgenesis
  • Vector control

ASJC Scopus subject areas

  • Microbiology (medical)

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