Microbial interactions during upper respiratory tract infections

Melinda M. Pettigrew, Janneane F. Gent, Krystal Revai, Janak Patel, Tasnee Chonmaitree

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus often colonize the nasopharynx. Children are susceptible to bacterial infections during or soon after upper respiratory tract infection (URI). We describe colonization with these 4 bacteria species alone or in combination during URI. Data were from a prospective cohort of healthy children 6 to 36 months of age followed up for 1 year. Analyses of 968 swabs from 212 children indicated that S. pneumoniae colonization is negatively associated with colonization by H. influenzae. Competitive interactions shifted when H. influenzae and M. catarrhalis colonized together. In this situation, the likelihood of colonization with all 3 species is higher. Negative associations were identified between S. pneumoniae and S. aureus and between H. influenzae and S. aureus. Polymicrobial interactions differed by number and species of bacteria present. Antimicrobial therapy and vaccination strategies targeting specific bacterial species may alter the flora in unforeseen ways.

Original languageEnglish (US)
Pages (from-to)1584-1591
Number of pages8
JournalEmerging Infectious Diseases
Volume14
Issue number10
DOIs
StatePublished - Oct 2008

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Microbial Interactions
Haemophilus influenzae
Respiratory Tract Infections
Streptococcus pneumoniae
Staphylococcus aureus
Moraxella (Branhamella) catarrhalis
Bacteria
Nasopharynx
Bacterial Infections
Vaccination

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology

Cite this

Pettigrew, M. M., Gent, J. F., Revai, K., Patel, J., & Chonmaitree, T. (2008). Microbial interactions during upper respiratory tract infections. Emerging Infectious Diseases, 14(10), 1584-1591. https://doi.org/10.3201/eid1410.080119

Microbial interactions during upper respiratory tract infections. / Pettigrew, Melinda M.; Gent, Janneane F.; Revai, Krystal; Patel, Janak; Chonmaitree, Tasnee.

In: Emerging Infectious Diseases, Vol. 14, No. 10, 10.2008, p. 1584-1591.

Research output: Contribution to journalArticle

Pettigrew, MM, Gent, JF, Revai, K, Patel, J & Chonmaitree, T 2008, 'Microbial interactions during upper respiratory tract infections', Emerging Infectious Diseases, vol. 14, no. 10, pp. 1584-1591. https://doi.org/10.3201/eid1410.080119
Pettigrew MM, Gent JF, Revai K, Patel J, Chonmaitree T. Microbial interactions during upper respiratory tract infections. Emerging Infectious Diseases. 2008 Oct;14(10):1584-1591. https://doi.org/10.3201/eid1410.080119
Pettigrew, Melinda M. ; Gent, Janneane F. ; Revai, Krystal ; Patel, Janak ; Chonmaitree, Tasnee. / Microbial interactions during upper respiratory tract infections. In: Emerging Infectious Diseases. 2008 ; Vol. 14, No. 10. pp. 1584-1591.
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