Microbial translocation in HIV infection: Causes, consequences and treatment opportunities

Netanya G. Sandler, Daniel C. Douek

Research output: Contribution to journalReview article

228 Scopus citations

Abstract

Systemic immune activation is increased in HIV-infected individuals, even in the setting of virus suppression with antiretroviral therapy. Although numerous factors may contribute, microbial products have recently emerged as potential drivers of this immune activation. In this Review, we describe the intestinal damage that occurs in HIV infection, the evidence for translocation of microbial products into the systemic circulation and the pathways by which these products activate the immune system. We also discuss novel therapies that disrupt the translocation of microbial products and the downstream effects of microbial translocation.

Original languageEnglish (US)
Pages (from-to)655-666
Number of pages12
JournalNature Reviews Microbiology
Volume10
Issue number9
DOIs
StatePublished - Sep 1 2012

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

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