Microbiota regulation of inflammatory bowel disease and colorectal cancer

Zhanju Liu, Anthony T. Cao, Yingzi Cong

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The host and microbiota have evolved mechanisms for coexistence over millions of years. Accumulating evidence indicates that a dynamic mutualism between the host and the commensal microbiota has important implications for health, and microbial colonization contributes to the maintenance of intestinal immune homeostasis. However, alterations in communication between the mucosal immune system and gut microbial communities have been implicated as the core defect that leads to chronic intestinal inflammation and cancer development. We will discuss the recent progress on how gut microbiota regulates intestinal homeostasis and the pathogenesis of inflammatory bowel disease and colorectal cancer.

Original languageEnglish (US)
Pages (from-to)543-552
Number of pages10
JournalSeminars in Cancer Biology
Volume23
Issue number6 PB
DOIs
StatePublished - Dec 2013

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Keywords

  • Colorectal cancer
  • Inflammatory bowel disease
  • Innate cells
  • Microbiota
  • T cells
  • Toll-like receptor

ASJC Scopus subject areas

  • Cancer Research

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