Microbiota-specific Th17 cells: Yin and Yang in regulation of inflammatory bowel disease

Wei Wu, Feidi Chen, Zhanju Liu, Yingzi Cong

    Research output: Contribution to journalReview article

    12 Scopus citations

    Abstract

    Multiple mechanisms are involved in regulation of host response to microbiota to maintain the intestinal homeostasis. Th17 cells are enriched in the intestinal lamina propria under steady conditions. Many studies have demonstrated that microbiota-reactive Th17 cells in the intestines mediate the pathogenesis of inflammatory bowel diseases. However, clinical trials of anti-interleukin-17A or anti-interleukin-17RA antibodies in patients with Crohn's Disease show no improvement or even exacerbation of disease. Accumulating data has also indicated that Th17 cells may provide a protective effect as well to the intestines from inflammatory insults under homeostasis regulation, even under inflammatory conditions. Thus both proinflammatory and anti-inflammatory functions of intestinal Th17 cells have emerged under various conditions. In this review article, we will summarize recent progresses of Th17 cells in regulation of intestinal homeostasis and in the pathogenesis of inflammatory bowel diseases.

    Original languageEnglish (US)
    Pages (from-to)1473-1482
    Number of pages10
    JournalInflammatory Bowel Diseases
    Volume22
    Issue number6
    DOIs
    StatePublished - Jun 1 2016

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    Keywords

    • IBD
    • microbiota
    • Th17

    ASJC Scopus subject areas

    • Gastroenterology
    • Immunology and Allergy

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