Microenvironment and Pathogenesis of Epithelial Ovarian Cancer

Antonio Saad, Wei Hu, Anil K. Sood

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Multiple genetic alterations play a role in the pathogenesis of ovarian cancer. Although many key proteins and pathways involved in ovarian carcinogenesis and metastasis have been discovered, knowledge of the early steps leading to malignancy remains poorly understood. This poor understanding stems from lack of data from early-stage cancers and absence of a well-established premalignant state universal to all ovarian cancer subtypes. Existing evidence suggests that ovarian cancers develop either through a stepwise mutation process (low-grade pathway), through genetic instability resulting in hastened metastasis (high-grade pathway), or more recently through what has been described as the "'fimbrial-ovarian' serous neoplasia theory." In this latter model, ovarian serous cancers evolve from premalignant lesions in the distal fallopian tube called tubal intraepithelial carcinoma. In this manuscript, we review key genetic and molecular changes that occur in cancer cell progression and suggest a model of ovarian cancer pathogenesis involving both tumor cell mutations and microenvironmental factors.

Original languageEnglish (US)
Pages (from-to)277-290
Number of pages14
JournalHormones and Cancer
Volume1
Issue number6
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Fingerprint

Ovarian Neoplasms
Neoplasms
Neoplasm Metastasis
Mutation
Fallopian Tubes
Carcinoma in Situ
Molecular Biology
Carcinogenesis
Ovarian epithelial cancer
Proteins

Keywords

  • Carcinogenesis
  • Ovarian cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Endocrine and Autonomic Systems

Cite this

Microenvironment and Pathogenesis of Epithelial Ovarian Cancer. / Saad, Antonio; Hu, Wei; Sood, Anil K.

In: Hormones and Cancer, Vol. 1, No. 6, 01.12.2010, p. 277-290.

Research output: Contribution to journalArticle

Saad, Antonio ; Hu, Wei ; Sood, Anil K. / Microenvironment and Pathogenesis of Epithelial Ovarian Cancer. In: Hormones and Cancer. 2010 ; Vol. 1, No. 6. pp. 277-290.
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