Microinjection of opioid antagonist into periaqueductal gray blocks formalin-induced alterations of substance P in spinal dorsal horn

J. H. Du, L. F. He

    Research output: Contribution to journalArticle

    Abstract

    Using formalin injected into the rat's hind paw as nociceptive stimulation, the effect of naloxone and β-endorphin (β-EP) antiserum microinjected into the periaqueductal gray (PAG) on the level of substance P like immunorcactivity (SPLI) of the spinal dorsal horn was observed. After formalin injection, a significant increase in SPLI was found as compared with the control (P < 0.01). After naloxone or β-EP antiserum microinjection, SPLI level in the dorsal horn was decreased (P < 0.05). It is thus suggested that nociceptive stimulation induce the release of β-EP in the PAG, which, in turn, modulate SP release in the spinal dorsal horn.

    Original languageEnglish (US)
    Pages (from-to)390-393
    Number of pages4
    JournalActa Physiologica Sinica
    Volume46
    Issue number4
    StatePublished - 1994

    Fingerprint

    Periaqueductal Gray
    Narcotic Antagonists
    Microinjections
    Substance P
    Formaldehyde
    Naloxone
    Immune Sera
    Endorphins
    Injections
    Spinal Cord Dorsal Horn

    Keywords

    • β-endorphin
    • formalin test
    • image processing
    • immunohistochemistry
    • naloxone
    • periaqueductal gray
    • spinal dorsal horn
    • substance P

    ASJC Scopus subject areas

    • Physiology

    Cite this

    Microinjection of opioid antagonist into periaqueductal gray blocks formalin-induced alterations of substance P in spinal dorsal horn. / Du, J. H.; He, L. F.

    In: Acta Physiologica Sinica, Vol. 46, No. 4, 1994, p. 390-393.

    Research output: Contribution to journalArticle

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